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- W46303329 abstract "Publisher SummaryThis chapter presents studies that are carried out in laboratory on the use of 32P-postlabelling to detect aromatic DNA adducts in animal and human tissues. The epidemiological studies of variations in human cancer incidences worldwide have led to the supposition that the majority of cancers are due, in some measure, to environmental factors. The etiology of some cancers may involve the simultaneous or sequential action of two or more such classes of agent. Experimental studies on laboratory animals have indicated that, following the administration of a carcinogenic dose of a chemical, a small proportion of the compound becomes covalently bound to cellular macromolecules in the tissues of the treated animals, and this binding is mediated through an electrophilic species either generated directly from the carcinogen or formed by metabolism. 32P-postlabelling is both highly sensitive and versatile and offers the possibility of detecting and analysing the presence of carcinogen adducts in DNA with little prior knowledge of their structures beyond some general assumptions about their likely chromatographic properties. The procedure requires only microgram quantities of DNA and is capable of detecting adducts at a frequency as low as one in 109–1010 nucleotides." @default.
- W46303329 created "2016-06-24" @default.
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- W46303329 date "1989-01-01" @default.
- W46303329 modified "2023-09-27" @default.
- W46303329 title "Detection by 32P-postlabelling of Carcinogen–DNA Adducts in Animals and Man" @default.
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- W46303329 doi "https://doi.org/10.1016/b978-0-12-388176-2.50016-3" @default.
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