Matches in SemOpenAlex for { <https://semopenalex.org/work/W463362004> ?p ?o ?g. }
Showing items 1 to 53 of
53
with 100 items per page.
- W463362004 abstract "One of the central pathways that enhances cell survival, division and migration, and is frequently deregulated in cancer is that of PI3K/PTEN (phosphoinositide 3- -kinase/phosphatase and tensin homolog). Although four genes encode PI3K p110 catalytic subunits and there are seven regulatory subunits, only the p110? and p110s isoforms and the p85 regulatory subunits are expressed ubiquitously in body tissues. When cells are activated to enter the cell cycle, the PI3K catalyze formation of the phosphatidylinositol (PI)(3,4,5)P3, a second messenger that triggers a number of important signaling cascades; PTEN subsequently reduces PI(3,4,5)P3 to basal levels. Activation of p110? precedes that of p110s at several points in the cell cycle, during G0/G1 and G1/S transitions and at mitosis entry; nonetheless, it is not known whether p110? and p110s activation are linked. In addition, PI3K activation precedes that of PTEN, but its ability to regulate PTEN activation has not been studied. We explored the potential connections between p110?, p110s and PTEN activation, and found that serum stimulation of cells promotes p110? and p110s association, which demonstrates oligomerization of PI3K catalytic subunits within the cells. Moreover, p110? regulates optimal p110s activation by direct association of the two isoforms. p85 dimerization through N-terminal SH3-BcR domains is necessary for p110?/p110s complex formation. PTEN is also incorporated into the p110?/p110s complex, and its activation depends on its association to this oligomer. Our results show that PI3K and PTEN activities regulate one other within a multimolecular complex that controls cell PI(3,4,5)P3 levels." @default.
- W463362004 created "2016-06-24" @default.
- W463362004 creator A5048203203 @default.
- W463362004 date "2014-07-16" @default.
- W463362004 modified "2023-09-27" @default.
- W463362004 title "Papel de la oligomerización de las PI3K de Clase IA p110a y p110ß en la regulación de la actividad de PTEN" @default.
- W463362004 hasPublicationYear "2014" @default.
- W463362004 type Work @default.
- W463362004 sameAs 463362004 @default.
- W463362004 citedByCount "0" @default.
- W463362004 crossrefType "dissertation" @default.
- W463362004 hasAuthorship W463362004A5048203203 @default.
- W463362004 hasConcept C104292427 @default.
- W463362004 hasConcept C104317684 @default.
- W463362004 hasConcept C11960822 @default.
- W463362004 hasConcept C153911025 @default.
- W463362004 hasConcept C178666793 @default.
- W463362004 hasConcept C185592680 @default.
- W463362004 hasConcept C2777609662 @default.
- W463362004 hasConcept C2779549131 @default.
- W463362004 hasConcept C2781322055 @default.
- W463362004 hasConcept C2781465904 @default.
- W463362004 hasConcept C53345823 @default.
- W463362004 hasConcept C55493867 @default.
- W463362004 hasConcept C62478195 @default.
- W463362004 hasConcept C86554907 @default.
- W463362004 hasConcept C86803240 @default.
- W463362004 hasConcept C93304396 @default.
- W463362004 hasConcept C95444343 @default.
- W463362004 hasConceptScore W463362004C104292427 @default.
- W463362004 hasConceptScore W463362004C104317684 @default.
- W463362004 hasConceptScore W463362004C11960822 @default.
- W463362004 hasConceptScore W463362004C153911025 @default.
- W463362004 hasConceptScore W463362004C178666793 @default.
- W463362004 hasConceptScore W463362004C185592680 @default.
- W463362004 hasConceptScore W463362004C2777609662 @default.
- W463362004 hasConceptScore W463362004C2779549131 @default.
- W463362004 hasConceptScore W463362004C2781322055 @default.
- W463362004 hasConceptScore W463362004C2781465904 @default.
- W463362004 hasConceptScore W463362004C53345823 @default.
- W463362004 hasConceptScore W463362004C55493867 @default.
- W463362004 hasConceptScore W463362004C62478195 @default.
- W463362004 hasConceptScore W463362004C86554907 @default.
- W463362004 hasConceptScore W463362004C86803240 @default.
- W463362004 hasConceptScore W463362004C93304396 @default.
- W463362004 hasConceptScore W463362004C95444343 @default.
- W463362004 hasLocation W4633620041 @default.
- W463362004 hasOpenAccess W463362004 @default.
- W463362004 hasPrimaryLocation W4633620041 @default.
- W463362004 isParatext "false" @default.
- W463362004 isRetracted "false" @default.
- W463362004 magId "463362004" @default.
- W463362004 workType "dissertation" @default.