Matches in SemOpenAlex for { <https://semopenalex.org/work/W46342181> ?p ?o ?g. }
Showing items 1 to 92 of
92
with 100 items per page.
- W46342181 endingPage "665" @default.
- W46342181 startingPage "653" @default.
- W46342181 abstract "BHK21 cells were shown by autoradiography to be arrested in G1 after growth in 0.2% fetal calf serum. Infection with Ad12 at high multiplicity resulted in the initiation of DNA synthesis in over 90% of the cells, beginning at 10–12 hours after infection. Quantitative correlations revealed that one infecting particle was sufficient to stimulate DNA synthesis, and did so with an efficiency equal to that of the initiation of T antigen (T Ag) synthesis. Simultaneous study of the same cells by autoradiography and immunofluorescence after low multiplicity infection demonstrated that DNA synthesis was initiated only in cells in which T Ag had also been synthesized. This fact implicated the transcription of a viral gene or genes in the initiation of DNA synthesis. Chromosome preparations showed that the infection was followed, beginning at 22 hours, by a sharp increase in mitotic activity. Initially, all resulting metaphase figures were intact except for a small number of chromatid breaks. Starting at 30 hours after infection such relatively “normal” metaphase figures disappeared, to be replaced by a continuing accumulation of cells which were in what appeared to be a highly disorganized mitosis with extensively fragmented or overcondensed chromosomes. By 48 hours after infection, 25% of the cells in the culture were in this condition. These results are taken to indicate that the virus initiates chromosomal DNA synthesis but that infection eventually results in extensive destruction of the cell genome, and thus the death of the cell." @default.
- W46342181 created "2016-06-24" @default.
- W46342181 creator A5061999267 @default.
- W46342181 date "1969-12-01" @default.
- W46342181 modified "2023-10-03" @default.
- W46342181 title "The response of BHK21 cells to infection with type 12 adenovirus" @default.
- W46342181 cites W1506123767 @default.
- W46342181 cites W1532427203 @default.
- W46342181 cites W1540235614 @default.
- W46342181 cites W1564868484 @default.
- W46342181 cites W1647596520 @default.
- W46342181 cites W1969276190 @default.
- W46342181 cites W1994500160 @default.
- W46342181 cites W2025500448 @default.
- W46342181 cites W2025886205 @default.
- W46342181 cites W2029234837 @default.
- W46342181 cites W2030606481 @default.
- W46342181 cites W2037002173 @default.
- W46342181 cites W2044484546 @default.
- W46342181 cites W2063609899 @default.
- W46342181 cites W2072674383 @default.
- W46342181 cites W2095274618 @default.
- W46342181 cites W2128326789 @default.
- W46342181 cites W2141048507 @default.
- W46342181 cites W2170183528 @default.
- W46342181 cites W340957314 @default.
- W46342181 cites W4236365054 @default.
- W46342181 cites W46342181 @default.
- W46342181 doi "https://doi.org/10.1016/0042-6822(69)90004-x" @default.
- W46342181 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/4902255" @default.
- W46342181 hasPublicationYear "1969" @default.
- W46342181 type Work @default.
- W46342181 sameAs 46342181 @default.
- W46342181 citedByCount "69" @default.
- W46342181 crossrefType "journal-article" @default.
- W46342181 hasAuthorship W46342181A5061999267 @default.
- W46342181 hasConcept C104317684 @default.
- W46342181 hasConcept C1491633281 @default.
- W46342181 hasConcept C153911025 @default.
- W46342181 hasConcept C159047783 @default.
- W46342181 hasConcept C203233990 @default.
- W46342181 hasConcept C2522874641 @default.
- W46342181 hasConcept C2776253266 @default.
- W46342181 hasConcept C30481170 @default.
- W46342181 hasConcept C54355233 @default.
- W46342181 hasConcept C552990157 @default.
- W46342181 hasConcept C64241487 @default.
- W46342181 hasConcept C70278784 @default.
- W46342181 hasConcept C81885089 @default.
- W46342181 hasConcept C85813293 @default.
- W46342181 hasConcept C86803240 @default.
- W46342181 hasConcept C93304396 @default.
- W46342181 hasConcept C95444343 @default.
- W46342181 hasConceptScore W46342181C104317684 @default.
- W46342181 hasConceptScore W46342181C1491633281 @default.
- W46342181 hasConceptScore W46342181C153911025 @default.
- W46342181 hasConceptScore W46342181C159047783 @default.
- W46342181 hasConceptScore W46342181C203233990 @default.
- W46342181 hasConceptScore W46342181C2522874641 @default.
- W46342181 hasConceptScore W46342181C2776253266 @default.
- W46342181 hasConceptScore W46342181C30481170 @default.
- W46342181 hasConceptScore W46342181C54355233 @default.
- W46342181 hasConceptScore W46342181C552990157 @default.
- W46342181 hasConceptScore W46342181C64241487 @default.
- W46342181 hasConceptScore W46342181C70278784 @default.
- W46342181 hasConceptScore W46342181C81885089 @default.
- W46342181 hasConceptScore W46342181C85813293 @default.
- W46342181 hasConceptScore W46342181C86803240 @default.
- W46342181 hasConceptScore W46342181C93304396 @default.
- W46342181 hasConceptScore W46342181C95444343 @default.
- W46342181 hasIssue "4" @default.
- W46342181 hasLocation W463421811 @default.
- W46342181 hasLocation W463421812 @default.
- W46342181 hasOpenAccess W46342181 @default.
- W46342181 hasPrimaryLocation W463421811 @default.
- W46342181 hasRelatedWork W1557750259 @default.
- W46342181 hasRelatedWork W1982152616 @default.
- W46342181 hasRelatedWork W2021752537 @default.
- W46342181 hasRelatedWork W2069390069 @default.
- W46342181 hasRelatedWork W2085549526 @default.
- W46342181 hasRelatedWork W2145191283 @default.
- W46342181 hasRelatedWork W2396816564 @default.
- W46342181 hasRelatedWork W2409057842 @default.
- W46342181 hasRelatedWork W2473201704 @default.
- W46342181 hasRelatedWork W4300291891 @default.
- W46342181 hasVolume "39" @default.
- W46342181 isParatext "false" @default.
- W46342181 isRetracted "false" @default.
- W46342181 magId "46342181" @default.
- W46342181 workType "article" @default.