FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W46374673> ?p ?o ?g. }

• W46374673 abstract "Metabolic profiling enables to understand biological processes responsible for differences in the content of metabolites among samples, such as healthy/diseased organisms, treated/control cultures, mutant/wild type genotypes, or different cultivars. In this work experimental procedures and data processing routines for non-targeted differential metabolic profiling based on LC-MS were developed and applied to different kinds of comparative experiments in plant systems. A major task was the assessment and adjustment of software tools for unbiased data processing which consists of raw data conversion into a universal format, noise reduction, chromatogram alignment, peak matching, normalization of signal intensities and comparative analysis. The open-source method XCMS is included for retention time alignment and peak matching across samples. An algorithm for normalization of signal intensities based on a method previously developed for transcript profiling was implemented. The applicability of the procedure is demonstrated on a plant-pathogen interaction: 19 metabolites in xylem sap of Brassica napus affected by the infection with vascular fungus Verticillium longisporum were detected. Two of the metabolites induced by infection were identified as salicylic acid and its glucoside. Furthermore, six yet unknown indolic polar metabolites were found only in infected plants. These compounds might be involved in the plant defense response. The methods developed in this project were applied to two other systems. Firstly, comparative analysis of metabolites from root exudates of phosphorus deficient/sufficient sugar beets revealed induced signals in phosphorus deficient plants, which were identified as salicylic acid and citramalic acid. Secondly, combination of genome diversity data on sesame with metabolic profiles of sesame seed extracts for a selected set of accessions provided information on the relationship between genomic and metabolic diversity in sesame and shed light on the role of selection for metabolite content during the evolution and domestication of this ancient crop." @default.
• W46374673 created "2016-06-24" @default.
• W46374673 creator A5063145599 @default.
• W46374673 date "2022-02-20" @default.
• W46374673 modified "2023-10-14" @default.
• W46374673 title "Development and application of LC-MS-based differential metabolic profiling in plant systems" @default.
• W46374673 cites W2111369365 @default.
• W46374673 doi "https://doi.org/10.53846/goediss-1972" @default.
• W46374673 hasPublicationYear "2022" @default.
• W46374673 type Work @default.
• W46374673 sameAs 46374673 @default.
• W46374673 citedByCount "1" @default.
• W46374673 countsByYear W463746732012 @default.
• W46374673 crossrefType "dissertation" @default.
• W46374673 hasAuthorship W46374673A5063145599 @default.
• W46374673 hasBestOaLocation W463746731 @default.
• W46374673 hasConcept C111919701 @default.
• W46374673 hasConcept C185592680 @default.
• W46374673 hasConcept C187191949 @default.
• W46374673 hasConcept C192989942 @default.
• W46374673 hasConcept C2777477808 @default.
• W46374673 hasConcept C2778221352 @default.
• W46374673 hasConcept C2994400308 @default.
• W46374673 hasConcept C41008148 @default.
• W46374673 hasConcept C43617362 @default.
• W46374673 hasConcept C55493867 @default.
• W46374673 hasConcept C62231903 @default.
• W46374673 hasConcept C70721500 @default.
• W46374673 hasConcept C86803240 @default.
• W46374673 hasConceptScore W46374673C111919701 @default.
• W46374673 hasConceptScore W46374673C185592680 @default.
• W46374673 hasConceptScore W46374673C187191949 @default.
• W46374673 hasConceptScore W46374673C192989942 @default.
• W46374673 hasConceptScore W46374673C2777477808 @default.
• W46374673 hasConceptScore W46374673C2778221352 @default.
• W46374673 hasConceptScore W46374673C2994400308 @default.
• W46374673 hasConceptScore W46374673C41008148 @default.
• W46374673 hasConceptScore W46374673C43617362 @default.
• W46374673 hasConceptScore W46374673C55493867 @default.
• W46374673 hasConceptScore W46374673C62231903 @default.
• W46374673 hasConceptScore W46374673C70721500 @default.
• W46374673 hasConceptScore W46374673C86803240 @default.
• W46374673 hasLocation W463746731 @default.
• W46374673 hasOpenAccess W46374673 @default.
• W46374673 hasPrimaryLocation W463746731 @default.
• W46374673 hasRelatedWork W1495744551 @default.
• W46374673 hasRelatedWork W1509926796 @default.
• W46374673 hasRelatedWork W2007897985 @default.
• W46374673 hasRelatedWork W2209046906 @default.
• W46374673 hasRelatedWork W2393940314 @default.
• W46374673 hasRelatedWork W2611694856 @default.
• W46374673 hasRelatedWork W2948400285 @default.
• W46374673 hasRelatedWork W3208282133 @default.
• W46374673 hasRelatedWork W4244585130 @default.
• W46374673 hasRelatedWork W4253097855 @default.
• W46374673 isParatext "false" @default.
• W46374673 isRetracted "false" @default.
• W46374673 magId "46374673" @default.
• W46374673 workType "dissertation" @default.