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- W46420498 abstract "AbstractThe description of multiscale processes in a unified and coherent fashion is of paramount importance in cardiovascular computational physiology. In this paper, a model that links the process of cardiac excitation and contraction from a cellular to a tissue level will be presented. A model of the action potential will be linked to the kinetics (attachment and detachment) of the proteins responsible for cardiac contraction (via the so called “crossbridges mechanism”). As a final step, the coupling of the calcium-dependent kinetics model to a higher-scale model of the left ventricle will complete the multi-scale model of cardiac dynamics from the sub-cellular level to the organ.KeywordsMulti-scale modeling and simulationcardiac modelingaction potentialdynamic calcium concentrationcrossbridge kinetics" @default.
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- W46420498 date "2011-01-01" @default.
- W46420498 modified "2023-09-27" @default.
- W46420498 title "Integration of the Calcium Dynamics in the Excitation Contraction Coupling Process within a Multiscale Model of the Left Ventricle" @default.
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- W46420498 doi "https://doi.org/10.1007/978-3-642-22586-4_56" @default.
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