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- W465577 abstract "1648 Objectives Microwave radiometry non-invasively detects natural microwave radiation from internal tissues with the intensity of the signal related to the tissue temperature. In contrast to imaging modalities such as PET/CT, this method is inexpensive, noninvasive and involves no exposure to radioactivity, detecting signal from low abundance physiologically-generated microwaves. The purpose of this study was to evaluate the performance of the microwave radiometer in the assessment of BAT activity in stimulated and suppressed conditions, and compare this to the imaging gold standard, FDG PET/CT. Methods Nineteen participants were scanned with radiometry and FDG PET/CT using a cold intervention to activate BAT. The cold intervention involved the participant placing their feet on a cold ice block while sitting in a cool room. Participants exhibiting BAT activity qualitatively on PET were scanned again with both methods following a BAT minimization protocol (exposure to a warm room and a 20 mg dose of propranolol). Radiometry was performed every five minutes for two hours prior to PET imaging during both warm and cold interventions. A grid of 15 - 20 points was drawn on the participant’s upper body (data was collected at each point) and a photo was taken for comparison with PET images. Results PET identified increased signal consistent with BAT activity in 11 of 19 participants. In 9 of these 11 participants, radiometry measurements collected during the cold study were modestly, but significantly higher on points located over areas of active brown fat on PET, than in points not exhibiting BAT activity (P Conclusions Passive microwave radiometry was shown to be feasible and, with major improvements, has the potential to non-invasively detect active brown fat using the participant’s non-activated skin areas as a control." @default.
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- W465577 date "2014-05-01" @default.
- W465577 modified "2023-09-27" @default.
- W465577 title "Passive microwave radiometry for the non-invasive detection of human brown fat: First human studies with direct correlation to FDG/PET" @default.
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