Matches in SemOpenAlex for { <https://semopenalex.org/work/W46609487> ?p ?o ?g. }
- W46609487 endingPage "3575" @default.
- W46609487 startingPage "3567" @default.
- W46609487 abstract "Primary mediastinal large B-cell lymphoma (PMBL) appears to be a distinct clinicopathologic entity among diffuse large B-cell lymphomas (DLBLs). To find molecular alterations associated with this disease, we compared the mRNAs expressed in 3 PMBLs and 3 peripheral DLBLs by differential display-reverse transcription (DDRT) and identified a mRNA specifically expressed in PMBLs. Sequence analysis showed that this mRNA is encoded by the MAL gene, the expression of which was shown to be restricted to the T-cell lineage during hematopoiesis. MAL gene expression was demonstrated by Northern blot and reverse transcription-polymerase chain reaction (RT-PCR) in 8 of 12 PMBLs. However, there was little or no MAL gene expression in 8 peripheral DLBLs. Immunohistochemical analysis evidenced expression of MAL protein in tumoral B cells restricted to the PMBL subtype. Finally, Southern blot studies did not demonstrate rearrangement of the MAL gene. Altogether, our results indicate that MAL expression is recurrent in PMBLs, providing further evidence that PMBL represents a distinct entity among DLBLs. Because MAL protein is located in detergent-insoluble glycolipid-enriched membrane (GEM) domains involved in lymphocyte signal transduction, abnormal expression of MAL protein in the B-lymphoid lineage may have significant implications in PMBL lymphomagenesis." @default.
- W46609487 created "2016-06-24" @default.
- W46609487 creator A5012900514 @default.
- W46609487 creator A5023973233 @default.
- W46609487 creator A5026554956 @default.
- W46609487 creator A5029455755 @default.
- W46609487 creator A5031041032 @default.
- W46609487 creator A5052452447 @default.
- W46609487 creator A5057049022 @default.
- W46609487 creator A5085259120 @default.
- W46609487 date "1999-11-15" @default.
- W46609487 modified "2023-10-18" @default.
- W46609487 title "The MAL Gene Is Expressed in Primary Mediastinal Large B-Cell Lymphoma" @default.
- W46609487 cites W100697462 @default.
- W46609487 cites W1535776410 @default.
- W46609487 cites W1560517371 @default.
- W46609487 cites W1580723864 @default.
- W46609487 cites W162250128 @default.
- W46609487 cites W1897935131 @default.
- W46609487 cites W1967331416 @default.
- W46609487 cites W1978368163 @default.
- W46609487 cites W1979254764 @default.
- W46609487 cites W1988397560 @default.
- W46609487 cites W1992504446 @default.
- W46609487 cites W1997726565 @default.
- W46609487 cites W1999743098 @default.
- W46609487 cites W2004723453 @default.
- W46609487 cites W2046053482 @default.
- W46609487 cites W2047721855 @default.
- W46609487 cites W2064701297 @default.
- W46609487 cites W2072122733 @default.
- W46609487 cites W2073906772 @default.
- W46609487 cites W2076121797 @default.
- W46609487 cites W2078587233 @default.
- W46609487 cites W2080653812 @default.
- W46609487 cites W2083358105 @default.
- W46609487 cites W2107202569 @default.
- W46609487 cites W2110453766 @default.
- W46609487 cites W2115037258 @default.
- W46609487 cites W2121936687 @default.
- W46609487 cites W2124314287 @default.
- W46609487 cites W2128243696 @default.
- W46609487 cites W2129214379 @default.
- W46609487 cites W2130780775 @default.
- W46609487 cites W2142840274 @default.
- W46609487 cites W216208948 @default.
- W46609487 cites W2166436914 @default.
- W46609487 cites W2170913213 @default.
- W46609487 cites W223415719 @default.
- W46609487 cites W2313165570 @default.
- W46609487 cites W2315308806 @default.
- W46609487 cites W2474537699 @default.
- W46609487 doi "https://doi.org/10.1182/blood.v94.10.3567.422k06_3567_3575" @default.
- W46609487 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/10552968" @default.
- W46609487 hasPublicationYear "1999" @default.
- W46609487 type Work @default.
- W46609487 sameAs 46609487 @default.
- W46609487 citedByCount "115" @default.
- W46609487 countsByYear W466094872013 @default.
- W46609487 countsByYear W466094872014 @default.
- W46609487 countsByYear W466094872015 @default.
- W46609487 countsByYear W466094872016 @default.
- W46609487 countsByYear W466094872017 @default.
- W46609487 countsByYear W466094872019 @default.
- W46609487 countsByYear W466094872020 @default.
- W46609487 countsByYear W466094872021 @default.
- W46609487 countsByYear W466094872022 @default.
- W46609487 countsByYear W466094872023 @default.
- W46609487 crossrefType "journal-article" @default.
- W46609487 hasAuthorship W46609487A5012900514 @default.
- W46609487 hasAuthorship W46609487A5023973233 @default.
- W46609487 hasAuthorship W46609487A5026554956 @default.
- W46609487 hasAuthorship W46609487A5029455755 @default.
- W46609487 hasAuthorship W46609487A5031041032 @default.
- W46609487 hasAuthorship W46609487A5052452447 @default.
- W46609487 hasAuthorship W46609487A5057049022 @default.
- W46609487 hasAuthorship W46609487A5085259120 @default.
- W46609487 hasConcept C104317684 @default.
- W46609487 hasConcept C105580179 @default.
- W46609487 hasConcept C150194340 @default.
- W46609487 hasConcept C153911025 @default.
- W46609487 hasConcept C159654299 @default.
- W46609487 hasConcept C177707886 @default.
- W46609487 hasConcept C203014093 @default.
- W46609487 hasConcept C2778453870 @default.
- W46609487 hasConcept C2779338263 @default.
- W46609487 hasConcept C2779916150 @default.
- W46609487 hasConcept C4692481 @default.
- W46609487 hasConcept C54355233 @default.
- W46609487 hasConcept C86803240 @default.
- W46609487 hasConceptScore W46609487C104317684 @default.
- W46609487 hasConceptScore W46609487C105580179 @default.
- W46609487 hasConceptScore W46609487C150194340 @default.
- W46609487 hasConceptScore W46609487C153911025 @default.
- W46609487 hasConceptScore W46609487C159654299 @default.
- W46609487 hasConceptScore W46609487C177707886 @default.
- W46609487 hasConceptScore W46609487C203014093 @default.
- W46609487 hasConceptScore W46609487C2778453870 @default.