FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W4662077> ?p ?o ?g. }

• W4662077 endingPage "262" @default.
• W4662077 startingPage "227" @default.
• W4662077 abstract "This chapter focuses on interleukin (IL)-4, which is produced by and affects many cell types. The biological milieu provides signals for the production of IL-4, and at the same time, the effects of IL-4 production depend on the timing and maturation/activation stage of many cell types. IL-4 influences the differentiation of effector cells at the level of antigen presentation, and activation of T cells. The presence of other cytokines can also dramatically change the outcome of an immune response. For cancer patients, local delivery of IL-4 by gene vectors may hold more promise than recombinant IL-4 by achieving high local concentration of the cytokine at the site of induction of an anti-tumor response. Development of more effective and regulatable gene delivery systems may allow to design combination strategies of multiple cytokines based on a deeper understanding of how each cytokine plays a role in the sequence of immune events. Understanding the receptors and their expression has led to the development of toxin-conjugated IL-4 for the treatment of cancer. Soluble forms of the IL-4 receptor may be important for patients with allergic diseases. In diseases in which excess T HI shifted balance is apparent, such as chronic inflammatory diseases, delivery of rIL-4 or IL-4 gene may be of therapeutic benefit. Understanding the signal transduction, and messenger molecules as well as the structure of IL-4, IL-4R, and their complexes may allow the development of specific inhibitors or enhancers of the complex biologic properties of IL-4." @default.
• W4662077 created "2016-06-24" @default.
• W4662077 creator A5002962815 @default.
• W4662077 creator A5024528047 @default.
• W4662077 creator A5058793243 @default.
• W4662077 date "2003-01-01" @default.
• W4662077 modified "2023-10-04" @default.
• W4662077 title "Interleukin-4" @default.
• W4662077 cites W1437694810 @default.
• W4662077 cites W1480450665 @default.
• W4662077 cites W1487217491 @default.
• W4662077 cites W1487414684 @default.
• W4662077 cites W1488377901 @default.
• W4662077 cites W1489090048 @default.
• W4662077 cites W1489361004 @default.
• W4662077 cites W1489815912 @default.
• W4662077 cites W1492996678 @default.
• W4662077 cites W1497205974 @default.
• W4662077 cites W1499492311 @default.
• W4662077 cites W1500581281 @default.
• W4662077 cites W1504005129 @default.
• W4662077 cites W1505115118 @default.
• W4662077 cites W1506022442 @default.
• W4662077 cites W1509650583 @default.
• W4662077 cites W1510632104 @default.
• W4662077 cites W1511759227 @default.
• W4662077 cites W1511825494 @default.
• W4662077 cites W1513939725 @default.
• W4662077 cites W151793644 @default.
• W4662077 cites W1520646806 @default.
• W4662077 cites W1520817333 @default.
• W4662077 cites W1521414677 @default.
• W4662077 cites W1522861336 @default.
• W4662077 cites W1523575552 @default.
• W4662077 cites W1533977973 @default.
• W4662077 cites W1535348459 @default.
• W4662077 cites W1536683563 @default.
• W4662077 cites W1538127929 @default.
• W4662077 cites W1539460627 @default.
• W4662077 cites W1542731022 @default.
• W4662077 cites W1542745127 @default.
• W4662077 cites W1543271400 @default.
• W4662077 cites W1543604048 @default.
• W4662077 cites W1545898053 @default.
• W4662077 cites W1546021870 @default.
• W4662077 cites W1547225947 @default.
• W4662077 cites W1548900061 @default.
• W4662077 cites W1551770882 @default.
• W4662077 cites W1555985183 @default.
• W4662077 cites W1557677191 @default.
• W4662077 cites W1557835716 @default.
• W4662077 cites W1559207481 @default.
• W4662077 cites W1565797631 @default.
• W4662077 cites W1566974294 @default.
• W4662077 cites W1570166102 @default.
• W4662077 cites W1570604385 @default.
• W4662077 cites W1570839422 @default.
• W4662077 cites W1572516801 @default.
• W4662077 cites W1582170718 @default.
• W4662077 cites W1583083211 @default.
• W4662077 cites W1583153554 @default.
• W4662077 cites W1583283620 @default.
• W4662077 cites W1586624722 @default.
• W4662077 cites W1594970574 @default.
• W4662077 cites W1595975240 @default.
• W4662077 cites W1598189172 @default.
• W4662077 cites W1601038998 @default.
• W4662077 cites W1602420025 @default.
• W4662077 cites W1603659997 @default.
• W4662077 cites W1607759608 @default.
• W4662077 cites W1608646358 @default.
• W4662077 cites W1609713897 @default.
• W4662077 cites W1622026143 @default.
• W4662077 cites W1622259699 @default.
• W4662077 cites W1628452905 @default.
• W4662077 cites W1629947638 @default.
• W4662077 cites W1630462424 @default.
• W4662077 cites W1646214634 @default.
• W4662077 cites W1648566400 @default.
• W4662077 cites W1649636482 @default.
• W4662077 cites W1655248452 @default.
• W4662077 cites W1672932778 @default.
• W4662077 cites W1673454808 @default.
• W4662077 cites W1675232304 @default.
• W4662077 cites W1703256892 @default.
• W4662077 cites W1750886276 @default.
• W4662077 cites W1754391675 @default.
• W4662077 cites W176326824 @default.
• W4662077 cites W1766031579 @default.
• W4662077 cites W1791618634 @default.
• W4662077 cites W1798181153 @default.
• W4662077 cites W1804168688 @default.
• W4662077 cites W1809540926 @default.
• W4662077 cites W1811383523 @default.
• W4662077 cites W1817153273 @default.
• W4662077 cites W1831514224 @default.
• W4662077 cites W1836425824 @default.
• W4662077 cites W1855929178 @default.

• next