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- W46712938 abstract "RNA processing is the term collectively used to describe the sequence of events through which the primary transcript from a gene acquires its mature form. Very soon after synthesis by RNA polymerase II begins, transcripts from nuclear protein-coding genes acquire a 5′ cap structure. The 3′ end of the messenger RNA (mRNA) is modified by the addition of a long string of adenosines in a process tightly linked to transcription termination. Finally, maturation of most eukaryotic mRNA precursors requires a process known as splicing, in which internal noncoding segments known as introns are removed and the coding segments, known as exons, are joined to produce functional mRNAs. In complex eukaryotes, exons are much smaller than introns and provide the functional unit initially recognized by the splicing machinery. Because the splicing signals found at the exon/intron boundaries have low information content, ancillary elements known as splicing enhancers and silencers are required to specify the precise sites of exon joining. Throughout their life cycles, mRNAs are decorated with proteins, some stably bound and others associated only transiently; thus, the functional form recognized by both the RNA-processing machinery and the translating ribosome is a ribonucleoprotein complex (mRNP). An important advance in recent years is the discovery that RNA-processing events are mechanistically coupled to transcription by RNA polymerase II." @default.
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- W46712938 date "2013-01-01" @default.
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- W46712938 title "Messenger RNA Processing in Eukaryotes" @default.
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- W46712938 doi "https://doi.org/10.1016/b978-0-12-378630-2.00627-7" @default.
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