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- W46789629 abstract "The loss of articular cartilage due to trauma or the degeneration caused by aging can result in debilitating conditions and osteoarthritis, because hyaline cartilage has a poor intrinsic capacity for healing. Articular cartilage defects are currently treated by several procedures, including microfracture and autologous chondrocyte transplantation, although fibrocartilaginous tissue is frequently formed instead of true hyaline cartilage. The development of induced pluripotent stem cells (iPSCs) offers a new cell source that is free of the ethical issues associated with the use of embryonic stem cells. In addition, the methods used to generate iPSCs and their differentiation into chondrocytes have been improved. As another cell source, a method for the direct conversion of fibroblasts to chondrocytes, which can generate hyaline cartilage, is also being developed." @default.
- W46789629 created "2016-06-24" @default.
- W46789629 creator A5066680249 @default.
- W46789629 date "2014-12-06" @default.
- W46789629 modified "2023-09-27" @default.
- W46789629 title "Cartilage Regeneration Using Induced Pluripotent Stem Cell Technologies" @default.
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- W46789629 doi "https://doi.org/10.1007/978-3-319-13266-2_6" @default.
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