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• W4679753 startingPage "959" @default.
• W4679753 abstract "The idea that the kidney is an organ needs to be tempered by the realization that it is the nephron that is the organ. Each nephron, as far as we know, is independent from other nephrons, and the kidney is to a first approximation a collection of these mini-organs put together in a complex three-dimensional assembly. The nephrons of all mammals are remarkably similar in size, function, and origin (as far as we know), and the differences among species are largely if not entirely due to the number of these units in the assembly, with mice having 10,000 and whales having 250 million in each kidney. But while the epithelial character of the nephron garners most of the attention, one needs to be reminded that the kidney has a very extensive vascular network with multiple distinct morphological and functional domains, as well as an abundant interstitial cell population that unfortunately is still poorly understood (see Kaissiling and Le Hir 1 for a review). While the taxonomy of the renal epithelial cells is nearly complete, that of the cells of the vascular and interstitial compartments awaits detailed characterization. Hence, analysis of renal regeneration after injury, as well as search for putative renal stem cells in the adult kidney, has essentially been restricted to the epithelial compartment. However, as epithelial cells are likely instructed by mesenchymal signals and epithelia-mesenchymal cross-talk is critical for renal epithelial differentiation and function, 2 there is a need for deeper understanding of the cell types that comprise the renal vascular and interstitial compartments, and their roles in kidney homeostasis and repair from injury. For example, in many organs including the kidney, mesenchymal cells with characteristics of precursor/stem cells have been found to reside near or in the vascular wall, [3] ; [4]  ; [5] but the exact origin and normal function of these cells is unknown." @default.
• W4679753 created "2016-06-24" @default.
• W4679753 creator A5022560285 @default.
• W4679753 creator A5056507553 @default.
• W4679753 date "2013-01-01" @default.
• W4679753 modified "2023-10-05" @default.
• W4679753 title "Stem Cells and Generation of New Cells in the Adult Kidney" @default.
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