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- W4692404 endingPage "285" @default.
- W4692404 startingPage "259" @default.
- W4692404 abstract "Zebrafish offers significant opportunities for the investigation of vertebrate development, evolution, physiology, and behavior and provides numerous models of human disease. Connecting zebrafish phenogenetic biology to that of humans and other vertebrates, however, requires the proper assignment of gene orthologies. Orthology assignments by phylogenetic analysis or by reciprocal best sequence similarity searches can lead to errors, especially in cases of gene duplication followed by gene loss or rapid lineage-specific gene evolution. Conserved synteny analysis provides a method that helps overcome such problems. Here we describe conserved synteny analysis for zebrafish genes and discuss the Synteny Database, a website specifically designed to identify conserved syntenies for zebrafish that takes into account the teleost genome duplication (TGD). We utilize the Synteny Database to demonstrate its power to resolve our understanding of the evolution of nerve growth factor receptor related genes, including Ngfr and the enigmatic Nradd. Finally, we compare conserved syntenies between zebrafish, stickleback, spotted gar, and human to understand the timing of chromosome rearrangements in teleost genome evolution. An improved understanding of gene histories that comes from the application of tools provided by the Synteny Database can facilitate the connectivity of zebrafish and human genomes." @default.
- W4692404 created "2016-06-24" @default.
- W4692404 creator A5060807605 @default.
- W4692404 creator A5061745861 @default.
- W4692404 creator A5084768099 @default.
- W4692404 date "2011-01-01" @default.
- W4692404 modified "2023-09-27" @default.
- W4692404 title "Conserved Synteny and the Zebrafish Genome" @default.
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- W4692404 doi "https://doi.org/10.1016/b978-0-12-374814-0.00015-x" @default.
- W4692404 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/21924168" @default.
- W4692404 hasPublicationYear "2011" @default.