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- W46996969 abstract "Abstract : The major aim is to determine the three-dimensional atomic structure of an organophosphorus acid anhydrolase (OPAA) by x ray crystallography. This structure is a prerequisite for remodeling the active site, in collaboration with scientists at ECBC and Geo-Centers, Inc. in order to enhance catalytic activity towards fluorinated U-type and other extremely toxic chemical warfare (CW) nerve agents. A decontamination system based on the remodeled OPAA not only provides rapid removal of CW agents, but is also enviromnentally safe and noncorrosive in nature. After overcoming the major difficulty in crystallizing OPAA, we have now determined by MAD and SAD techniques and refined the crystal structure of OPAA to 2.5 A resolution. The structure analysis of OPAA with the bound enzyme inhibitor MIPAFOX (N,N'-di-isopropylphosphorodiamidic fluoride) is in progress." @default.
- W46996969 created "2016-06-24" @default.
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- W46996969 date "2004-05-09" @default.
- W46996969 modified "2023-09-27" @default.
- W46996969 title "Atomic Crystal Structure of an Organophosphorus Acid Anhydrolase" @default.
- W46996969 doi "https://doi.org/10.21236/ada422943" @default.
- W46996969 hasPublicationYear "2004" @default.
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