Matches in SemOpenAlex for { <https://semopenalex.org/work/W47061825> ?p ?o ?g. }
Showing items 1 to 63 of
63
with 100 items per page.
- W47061825 endingPage "8" @default.
- W47061825 startingPage "4" @default.
- W47061825 abstract "Acute pulmonary embolism (PE) is the life-threatening condition with high incidence and mortality where the death is the result of pulmonary hypertension followed by right side heart failure. There are two important mechanisms concerned in the development of pulmonary embolism--induced pulmonary hypertension--mechanic obstruction of pulmonary vessels by the embolus and vasoconstriction. The effect of mechanic obstruction is quite clear, in contrast to the role of vasoconstriction. Activation of endothelial cells, thrombocytes and leucocytes, which release vasoconstricting substances (ET-1, 5-HT etc.) and production of reactive oxygen species (ROS) are the most important factors causing the vasoconstriction after PE. ROS are produced as a result of hypoxia, increased (and decreased) shear stress and are released from activated leukocytes. Vasoconstriction after PE is caused by change of conformation voltage-gated potassium channels, the decrease of vasodilatation effect of NO and activation of matrix metalloproteinases.. Most of the current therapeutic protocols in PE are focused on mechanic obstruction of pulmonary vessels. Thus, the research of the role of vasoconstriction in PE and potentially protective factors in vasocostriction--induced injury represent clinically highly important field." @default.
- W47061825 created "2016-06-24" @default.
- W47061825 creator A5020821024 @default.
- W47061825 date "2012-01-01" @default.
- W47061825 modified "2023-09-23" @default.
- W47061825 title "[Pathophysiology of development of pulmonary hypertension after acute pulmonary embolism]." @default.
- W47061825 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/22737942" @default.
- W47061825 hasPublicationYear "2012" @default.
- W47061825 type Work @default.
- W47061825 sameAs 47061825 @default.
- W47061825 citedByCount "1" @default.
- W47061825 countsByYear W470618252022 @default.
- W47061825 crossrefType "journal-article" @default.
- W47061825 hasAuthorship W47061825A5020821024 @default.
- W47061825 hasConcept C120770815 @default.
- W47061825 hasConcept C126322002 @default.
- W47061825 hasConcept C164705383 @default.
- W47061825 hasConcept C178790620 @default.
- W47061825 hasConcept C185592680 @default.
- W47061825 hasConcept C2776265017 @default.
- W47061825 hasConcept C2779961880 @default.
- W47061825 hasConcept C2780930700 @default.
- W47061825 hasConcept C2780940725 @default.
- W47061825 hasConcept C29323129 @default.
- W47061825 hasConcept C42219234 @default.
- W47061825 hasConcept C540031477 @default.
- W47061825 hasConcept C71924100 @default.
- W47061825 hasConcept C7836513 @default.
- W47061825 hasConceptScore W47061825C120770815 @default.
- W47061825 hasConceptScore W47061825C126322002 @default.
- W47061825 hasConceptScore W47061825C164705383 @default.
- W47061825 hasConceptScore W47061825C178790620 @default.
- W47061825 hasConceptScore W47061825C185592680 @default.
- W47061825 hasConceptScore W47061825C2776265017 @default.
- W47061825 hasConceptScore W47061825C2779961880 @default.
- W47061825 hasConceptScore W47061825C2780930700 @default.
- W47061825 hasConceptScore W47061825C2780940725 @default.
- W47061825 hasConceptScore W47061825C29323129 @default.
- W47061825 hasConceptScore W47061825C42219234 @default.
- W47061825 hasConceptScore W47061825C540031477 @default.
- W47061825 hasConceptScore W47061825C71924100 @default.
- W47061825 hasConceptScore W47061825C7836513 @default.
- W47061825 hasIssue "1" @default.
- W47061825 hasLocation W470618251 @default.
- W47061825 hasOpenAccess W47061825 @default.
- W47061825 hasPrimaryLocation W470618251 @default.
- W47061825 hasRelatedWork W1515836815 @default.
- W47061825 hasRelatedWork W2023170905 @default.
- W47061825 hasRelatedWork W2032306832 @default.
- W47061825 hasRelatedWork W2036100871 @default.
- W47061825 hasRelatedWork W2098120608 @default.
- W47061825 hasRelatedWork W2166985476 @default.
- W47061825 hasRelatedWork W2462913190 @default.
- W47061825 hasRelatedWork W2463110717 @default.
- W47061825 hasRelatedWork W301035058 @default.
- W47061825 hasRelatedWork W335837758 @default.
- W47061825 hasVolume "61" @default.
- W47061825 isParatext "false" @default.
- W47061825 isRetracted "false" @default.
- W47061825 magId "47061825" @default.
- W47061825 workType "article" @default.