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- W47085494 abstract "Toxicologic pathology concerns the effect of potentially noxious products on the body. Toxicologic pathology differs in approach and methodology from diagnostic pathology. Many short-term studies are conducted to elucidate the mechanism of action of the test compound, to give some idea of its toxicity and to identify possible target organs. These studies incorporate standard histopathologic and clinical pathologic techniques. Sometimes specialized techniques, including electron microscopy, immunohistochemistry, autoradiography, and quantitative morphometry, are warranted. The first goal of toxicologic pathology is to establish the precise degree of risk posed to the test animals under the controlled exposure conditions. The process is similar to diagnostic pathology in lesion evaluation but differs in the manner in which data are compiled. Most of the factors that influence evaluation of morphologic change (e.g., poor fixation of tissue) have the undesirable effect of increasing the variability within groups and subsequently the range of data that the pathologist is forced to accept, which decreases the sensitivity of the methods used. The chapter describes factors influencing the evaluation of altered morphology." @default.
- W47085494 created "2016-06-24" @default.
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- W47085494 date "2002-01-01" @default.
- W47085494 modified "2023-09-28" @default.
- W47085494 title "Basic Techniques" @default.
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- W47085494 doi "https://doi.org/10.1016/b978-012330215-1/50009-0" @default.
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