Matches in SemOpenAlex for { <https://semopenalex.org/work/W47133697> ?p ?o ?g. }
- W47133697 endingPage "119" @default.
- W47133697 startingPage "99" @default.
- W47133697 abstract "During development inside red blood cells (RBCs), Plasmodium falciparum malaria parasites export a number of proteins beyond the confines of their own plasma membrane where they associate with the RBC membrane skeleton. Here they participate in protein-protein interactions with both RBC proteins and other parasite proteins and assemble into complex multi-component structures known as knobs. These interactions cause profound changes to the rheological properties of RBCs, particularly increased cell resistance to deformation and increased adhesiveness, which underpin the severe and often fatal clinical manifestations of falciparum malaria. Here, we bring together recent insights that have been made into understanding the molecular mechanisms that underlie these parasite-induced alterations to RBCs. We describe some of the well-established methods that have been used to quantify the altered rheological properties of parasitized RBCs (PRBCs) and discuss emerging techniques that have already begun to advance our knowledge of the molecular basis of this important human disease. Finally, we suggest potential new avenues for rheological anti-malaria therapy." @default.
- W47133697 created "2016-06-24" @default.
- W47133697 creator A5039556389 @default.
- W47133697 creator A5061151383 @default.
- W47133697 creator A5071833047 @default.
- W47133697 date "2014-01-01" @default.
- W47133697 modified "2023-10-18" @default.
- W47133697 title "The cellular and molecular rheology of malaria" @default.
- W47133697 cites W1499295256 @default.
- W47133697 cites W1499483096 @default.
- W47133697 cites W1513454216 @default.
- W47133697 cites W1537061132 @default.
- W47133697 cites W1550911363 @default.
- W47133697 cites W1552272164 @default.
- W47133697 cites W1566850314 @default.
- W47133697 cites W1579859858 @default.
- W47133697 cites W1755848100 @default.
- W47133697 cites W1800815393 @default.
- W47133697 cites W191400563 @default.
- W47133697 cites W1930237957 @default.
- W47133697 cites W1955203614 @default.
- W47133697 cites W1970908717 @default.
- W47133697 cites W1971705093 @default.
- W47133697 cites W1975685743 @default.
- W47133697 cites W1977818394 @default.
- W47133697 cites W1981825496 @default.
- W47133697 cites W1984347606 @default.
- W47133697 cites W1985113950 @default.
- W47133697 cites W1987002047 @default.
- W47133697 cites W1991873268 @default.
- W47133697 cites W1992644072 @default.
- W47133697 cites W1993775596 @default.
- W47133697 cites W1994885891 @default.
- W47133697 cites W1995685261 @default.
- W47133697 cites W1995703816 @default.
- W47133697 cites W1996079166 @default.
- W47133697 cites W1999153843 @default.
- W47133697 cites W2001075170 @default.
- W47133697 cites W2002887973 @default.
- W47133697 cites W2004883880 @default.
- W47133697 cites W2008900005 @default.
- W47133697 cites W2009106952 @default.
- W47133697 cites W2009448974 @default.
- W47133697 cites W2011516987 @default.
- W47133697 cites W2011687418 @default.
- W47133697 cites W2013342412 @default.
- W47133697 cites W2014403739 @default.
- W47133697 cites W2015082048 @default.
- W47133697 cites W2015716731 @default.
- W47133697 cites W2018447485 @default.
- W47133697 cites W2019003837 @default.
- W47133697 cites W2019496912 @default.
- W47133697 cites W2019851585 @default.
- W47133697 cites W2020755315 @default.
- W47133697 cites W2020944594 @default.
- W47133697 cites W2021385369 @default.
- W47133697 cites W2021874649 @default.
- W47133697 cites W2022494467 @default.
- W47133697 cites W2023114159 @default.
- W47133697 cites W2024377496 @default.
- W47133697 cites W2027599829 @default.
- W47133697 cites W2029372771 @default.
- W47133697 cites W2029552204 @default.
- W47133697 cites W2029913415 @default.
- W47133697 cites W2032620898 @default.
- W47133697 cites W2033260733 @default.
- W47133697 cites W2035205417 @default.
- W47133697 cites W2037042354 @default.
- W47133697 cites W2039499182 @default.
- W47133697 cites W2039888550 @default.
- W47133697 cites W2041995719 @default.
- W47133697 cites W2043107447 @default.
- W47133697 cites W2043873794 @default.
- W47133697 cites W2048368768 @default.
- W47133697 cites W2048812572 @default.
- W47133697 cites W2049237667 @default.
- W47133697 cites W2049729778 @default.
- W47133697 cites W2052224066 @default.
- W47133697 cites W2053558413 @default.
- W47133697 cites W2053758185 @default.
- W47133697 cites W2057463574 @default.
- W47133697 cites W2057625659 @default.
- W47133697 cites W2057652826 @default.
- W47133697 cites W2057719162 @default.
- W47133697 cites W2062396541 @default.
- W47133697 cites W2063384989 @default.
- W47133697 cites W2064830352 @default.
- W47133697 cites W2065769905 @default.
- W47133697 cites W2066686101 @default.
- W47133697 cites W2066736329 @default.
- W47133697 cites W2068058223 @default.
- W47133697 cites W2068736618 @default.
- W47133697 cites W2070257791 @default.
- W47133697 cites W2070999559 @default.
- W47133697 cites W2072485941 @default.
- W47133697 cites W2073029236 @default.
- W47133697 cites W2073879684 @default.
- W47133697 cites W2075412398 @default.