Matches in SemOpenAlex for { <https://semopenalex.org/work/W47214699> ?p ?o ?g. }
Showing items 1 to 89 of
89
with 100 items per page.
- W47214699 endingPage "113" @default.
- W47214699 startingPage "103" @default.
- W47214699 abstract "Atg16L1 is an essential factor for canonical autophagy, a conserved bulk degradation system in all eukaryotes. Atg16L1 forms a complex with Atg12-conjugated Atg5, i.e., an Atg16L1–5–12 complex, and promotes elongation of isolation membranes possibly by recruiting LC3 and by facilitating its lipidation. Because of its critical role in canonical autophagy, cells from Atg16L1-deficient mice exhibit complete loss of autophagosome formation. Interestingly, the intestinal Paneth cells of Atg16L1-deficient mice exhibit a secretion defect, but the mechanism by which Atg16L1 regulates the secretory pathway is poorly understood. We recently reported the finding that Atg16L1 localizes on hormone-containing dense-core vesicles in neuroendocrine PC12 cells independent of canonical autophagy and that small GTPase Rab33A recruits the Atg16L1–5–12 complex to dense-core vesicles. We also found that knockdown of Atg16L1 in PC12 cells caused a dramatic reduction in hormone secretion independent of the autophagic activity of the cells. Our findings indicate that, in addition to its role in autophagy, Atg16L1 (or the Atg16L1–5–12 complex) regulates hormone secretion from dense-core vesicles, most likely by acting as a Rab33A effector in particular cell types, including PC12 cells." @default.
- W47214699 created "2016-06-24" @default.
- W47214699 creator A5006129467 @default.
- W47214699 creator A5081539048 @default.
- W47214699 date "2015-01-01" @default.
- W47214699 modified "2023-09-24" @default.
- W47214699 title "Atg16L1 Protein Regulates Hormone Secretion Independent of Autophagy" @default.
- W47214699 cites W1578142161 @default.
- W47214699 cites W1966227354 @default.
- W47214699 cites W1985478291 @default.
- W47214699 cites W1994668150 @default.
- W47214699 cites W1994823455 @default.
- W47214699 cites W1996068251 @default.
- W47214699 cites W1999477136 @default.
- W47214699 cites W2011197968 @default.
- W47214699 cites W2025087599 @default.
- W47214699 cites W2033403225 @default.
- W47214699 cites W2037127469 @default.
- W47214699 cites W2040157483 @default.
- W47214699 cites W2043270577 @default.
- W47214699 cites W2052403003 @default.
- W47214699 cites W2064741210 @default.
- W47214699 cites W2067692987 @default.
- W47214699 cites W2088983693 @default.
- W47214699 cites W2096853390 @default.
- W47214699 cites W2109070574 @default.
- W47214699 cites W2122031852 @default.
- W47214699 cites W2122234266 @default.
- W47214699 cites W2126660909 @default.
- W47214699 cites W2131089732 @default.
- W47214699 cites W2135901758 @default.
- W47214699 cites W2143035803 @default.
- W47214699 cites W2146072506 @default.
- W47214699 cites W2149771125 @default.
- W47214699 cites W2150168624 @default.
- W47214699 cites W2150598695 @default.
- W47214699 cites W2153685214 @default.
- W47214699 doi "https://doi.org/10.1016/b978-0-12-801043-3.00006-6" @default.
- W47214699 hasPublicationYear "2015" @default.
- W47214699 type Work @default.
- W47214699 sameAs 47214699 @default.
- W47214699 citedByCount "0" @default.
- W47214699 crossrefType "book-chapter" @default.
- W47214699 hasAuthorship W47214699A5006129467 @default.
- W47214699 hasAuthorship W47214699A5081539048 @default.
- W47214699 hasConcept C185592680 @default.
- W47214699 hasConcept C187092789 @default.
- W47214699 hasConcept C190283241 @default.
- W47214699 hasConcept C193469717 @default.
- W47214699 hasConcept C203522944 @default.
- W47214699 hasConcept C2780329694 @default.
- W47214699 hasConcept C2781000418 @default.
- W47214699 hasConcept C49039625 @default.
- W47214699 hasConcept C55493867 @default.
- W47214699 hasConcept C86803240 @default.
- W47214699 hasConcept C95444343 @default.
- W47214699 hasConceptScore W47214699C185592680 @default.
- W47214699 hasConceptScore W47214699C187092789 @default.
- W47214699 hasConceptScore W47214699C190283241 @default.
- W47214699 hasConceptScore W47214699C193469717 @default.
- W47214699 hasConceptScore W47214699C203522944 @default.
- W47214699 hasConceptScore W47214699C2780329694 @default.
- W47214699 hasConceptScore W47214699C2781000418 @default.
- W47214699 hasConceptScore W47214699C49039625 @default.
- W47214699 hasConceptScore W47214699C55493867 @default.
- W47214699 hasConceptScore W47214699C86803240 @default.
- W47214699 hasConceptScore W47214699C95444343 @default.
- W47214699 hasFunder F4320320912 @default.
- W47214699 hasFunder F4320323514 @default.
- W47214699 hasFunder F4320334764 @default.
- W47214699 hasLocation W472146991 @default.
- W47214699 hasOpenAccess W47214699 @default.
- W47214699 hasPrimaryLocation W472146991 @default.
- W47214699 hasRelatedWork W2073047120 @default.
- W47214699 hasRelatedWork W2122234266 @default.
- W47214699 hasRelatedWork W2476750798 @default.
- W47214699 hasRelatedWork W2604133228 @default.
- W47214699 hasRelatedWork W2795682982 @default.
- W47214699 hasRelatedWork W2985644125 @default.
- W47214699 hasRelatedWork W3001120918 @default.
- W47214699 hasRelatedWork W3044064086 @default.
- W47214699 hasRelatedWork W3130988593 @default.
- W47214699 hasRelatedWork W4243182520 @default.
- W47214699 isParatext "false" @default.
- W47214699 isRetracted "false" @default.
- W47214699 magId "47214699" @default.
- W47214699 workType "book-chapter" @default.