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- W47379844 abstract "Objectives Studies have demonstrated abnormal pulse wave analysis (PWA) at the time of and after the diagnosis of pre-eclampsia. However, there remains a paucity of data concerning its predictive value. In addition, new cuff-based technology in measuring PWA is now available, removing the need for using applanation tonometry, which is highly operator-dependent. The aim of our study was to assess the utility of first trimester PWA using a cuff-based device and its potential role in predicting early-onset pre-eclampsia (delivery before 34 weeks). Methods Early-onset pre-eclampsia risk is currently determined by an algorithm consisting of maternal history, mean arterial pressure, uterine artery pulsatility index and pregnancy-associated plasma protein A at 11-13+6 weeks gestation. PWA was measured using a cuff-based device (SphygmoCor XCEL) at this time point. The differences in augmentation pressure (AP), augmentation index (AIx), and the heart-rate corrected augmentation index (AIx75) amongst the different risk groups were determined using t -tests. Results 746 women were studied. The mean age was 33.0 years (95% CI: 32.6 – 33.3 years). 132 were found to have ⩾1% risk (group A), and 36 had ⩾5% risk (group B). For group A, all three parameters were elevated but not statistically significant compared to women with p = 0.08), AIx: 15.2 vs. 12.8 ( p = 0.13), AIx75: 19.8 vs. 17.2 ( p = 0.11)]. For group B, all three parameters were significantly elevated compared to women with p = 0.006), AIx: 19.1 vs. 12.9 ( p = 0.02), AIx75: 23.9 vs. 17.4 ( p = 0.02)]. Conclusions Women found to be at high risk of developing early pre-eclampsia were also found to have higher PWA parameters. This suggests that the generalized vascular changes associated with pre-eclampsia are present at this early stage of pregnancy. This simple technique may be useful in assessing the risk of developing early-onset pre-eclampsia. Disclosures P. Lan: None. J. Hyett: None. A. Gillin: None." @default.
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- W47379844 date "2015-01-01" @default.
- W47379844 modified "2023-09-27" @default.
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- W47379844 doi "https://doi.org/10.1016/j.preghy.2014.10.054" @default.
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