Matches in SemOpenAlex for { <https://semopenalex.org/work/W47388542> ?p ?o ?g. }
Showing items 1 to 81 of
81
with 100 items per page.
- W47388542 endingPage "66" @default.
- W47388542 startingPage "61" @default.
- W47388542 abstract "This chapter describes work to combat obesity and obesity-related diseases by increasing energy expenditure. We build on a recent finding by others and us that has demonstrated the existence of significant amounts of metabolically active brown adipose tissue (BAT) in healthy adult humans. BAT has the unique capacity to regulate energy expenditure by a process called adaptive thermogenesis, which dissipates chemical energy to produce heat. If fully active, the BAT depots of adult humans may burn an amount of energy equivalent to about 4 kg of white adipose tissue (WAT) per year. The identification of BAT in adult humans opens completely new avenues of therapeutic intervention, which will be discussed in the context of previous findings regarding forkhead genes and their importance for recruitment of BAT in vivo. FOXC2 acts both as a “sensitizer” of PKA signaling in BAT and a regulator of BAT vascularization. In light of this, human BAT function is a highly relevant medical issue, and points of interest are: 1) to further understand substrate metabolism and the systemic importance of human BAT; 2) to investigate the possibility of distinct classes of human BAT cells; 3) to characterize the gene regulatory networks that control BAT differentiation and metabolic activity, and 4) to identify putative drug targets for BAT activation and to explore their physiological importance." @default.
- W47388542 created "2016-06-24" @default.
- W47388542 creator A5002161503 @default.
- W47388542 date "2010-01-01" @default.
- W47388542 modified "2023-09-27" @default.
- W47388542 title "Brown Adipose Tissue In Humans: A New Target for Anti-Obesity Therapy" @default.
- W47388542 cites W1575263278 @default.
- W47388542 cites W1965079305 @default.
- W47388542 cites W1968963111 @default.
- W47388542 cites W1997432717 @default.
- W47388542 cites W2005827500 @default.
- W47388542 cites W2011564895 @default.
- W47388542 cites W2014671368 @default.
- W47388542 cites W2014702327 @default.
- W47388542 cites W2014860237 @default.
- W47388542 cites W2025530025 @default.
- W47388542 cites W2040328785 @default.
- W47388542 cites W2057194981 @default.
- W47388542 cites W2062073832 @default.
- W47388542 cites W2073706859 @default.
- W47388542 cites W2090848174 @default.
- W47388542 cites W2104183837 @default.
- W47388542 cites W2104827888 @default.
- W47388542 cites W2114821999 @default.
- W47388542 cites W2123106337 @default.
- W47388542 cites W2151244639 @default.
- W47388542 cites W2152101492 @default.
- W47388542 cites W321075287 @default.
- W47388542 doi "https://doi.org/10.1007/978-3-642-13517-0_5" @default.
- W47388542 hasPublicationYear "2010" @default.
- W47388542 type Work @default.
- W47388542 sameAs 47388542 @default.
- W47388542 citedByCount "1" @default.
- W47388542 countsByYear W473885422018 @default.
- W47388542 crossrefType "book-chapter" @default.
- W47388542 hasAuthorship W47388542A5002161503 @default.
- W47388542 hasConcept C104317684 @default.
- W47388542 hasConcept C134018914 @default.
- W47388542 hasConcept C151279926 @default.
- W47388542 hasConcept C151730666 @default.
- W47388542 hasConcept C151955695 @default.
- W47388542 hasConcept C169760540 @default.
- W47388542 hasConcept C171089720 @default.
- W47388542 hasConcept C2779343474 @default.
- W47388542 hasConcept C2780642333 @default.
- W47388542 hasConcept C2988147884 @default.
- W47388542 hasConcept C54355233 @default.
- W47388542 hasConcept C6929976 @default.
- W47388542 hasConcept C86803240 @default.
- W47388542 hasConceptScore W47388542C104317684 @default.
- W47388542 hasConceptScore W47388542C134018914 @default.
- W47388542 hasConceptScore W47388542C151279926 @default.
- W47388542 hasConceptScore W47388542C151730666 @default.
- W47388542 hasConceptScore W47388542C151955695 @default.
- W47388542 hasConceptScore W47388542C169760540 @default.
- W47388542 hasConceptScore W47388542C171089720 @default.
- W47388542 hasConceptScore W47388542C2779343474 @default.
- W47388542 hasConceptScore W47388542C2780642333 @default.
- W47388542 hasConceptScore W47388542C2988147884 @default.
- W47388542 hasConceptScore W47388542C54355233 @default.
- W47388542 hasConceptScore W47388542C6929976 @default.
- W47388542 hasConceptScore W47388542C86803240 @default.
- W47388542 hasLocation W473885421 @default.
- W47388542 hasOpenAccess W47388542 @default.
- W47388542 hasPrimaryLocation W473885421 @default.
- W47388542 hasRelatedWork W1820550290 @default.
- W47388542 hasRelatedWork W1965875712 @default.
- W47388542 hasRelatedWork W2031710218 @default.
- W47388542 hasRelatedWork W2093477572 @default.
- W47388542 hasRelatedWork W2222789067 @default.
- W47388542 hasRelatedWork W2295312485 @default.
- W47388542 hasRelatedWork W2317656562 @default.
- W47388542 hasRelatedWork W2586936141 @default.
- W47388542 hasRelatedWork W2951198025 @default.
- W47388542 hasRelatedWork W4285039684 @default.
- W47388542 isParatext "false" @default.
- W47388542 isRetracted "false" @default.
- W47388542 magId "47388542" @default.
- W47388542 workType "book-chapter" @default.