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• W47407007 abstract "Research Article1 September 1988free access A molecular map of the chicken major histocompatibility complex: the class II beta genes are closely linked to the class I genes and the nucleolar organizer. F. Guillemot F. Guillemot Institut d'Embryologie du CNRS et du Collège de France, Nogent sur Marne. Search for more papers by this author A. Billault A. Billault Institut d'Embryologie du CNRS et du Collège de France, Nogent sur Marne. Search for more papers by this author O. Pourquié O. Pourquié Institut d'Embryologie du CNRS et du Collège de France, Nogent sur Marne. Search for more papers by this author G. Béhar G. Béhar Institut d'Embryologie du CNRS et du Collège de France, Nogent sur Marne. Search for more papers by this author A. M. Chaussé A. M. Chaussé Institut d'Embryologie du CNRS et du Collège de France, Nogent sur Marne. Search for more papers by this author R. Zoorob R. Zoorob Institut d'Embryologie du CNRS et du Collège de France, Nogent sur Marne. Search for more papers by this author G. Kreibich G. Kreibich Institut d'Embryologie du CNRS et du Collège de France, Nogent sur Marne. Search for more papers by this author C. Auffray C. Auffray Institut d'Embryologie du CNRS et du Collège de France, Nogent sur Marne. Search for more papers by this author F. Guillemot F. Guillemot Institut d'Embryologie du CNRS et du Collège de France, Nogent sur Marne. Search for more papers by this author A. Billault A. Billault Institut d'Embryologie du CNRS et du Collège de France, Nogent sur Marne. Search for more papers by this author O. Pourquié O. Pourquié Institut d'Embryologie du CNRS et du Collège de France, Nogent sur Marne. Search for more papers by this author G. Béhar G. Béhar Institut d'Embryologie du CNRS et du Collège de France, Nogent sur Marne. Search for more papers by this author A. M. Chaussé A. M. Chaussé Institut d'Embryologie du CNRS et du Collège de France, Nogent sur Marne. Search for more papers by this author R. Zoorob R. Zoorob Institut d'Embryologie du CNRS et du Collège de France, Nogent sur Marne. Search for more papers by this author G. Kreibich G. Kreibich Institut d'Embryologie du CNRS et du Collège de France, Nogent sur Marne. Search for more papers by this author C. Auffray C. Auffray Institut d'Embryologie du CNRS et du Collège de France, Nogent sur Marne. Search for more papers by this author Author Information F. Guillemot1, A. Billault1, O. Pourquié1, G. Béhar1, A. M. Chaussé1, R. Zoorob1, G. Kreibich1 and C. Auffray1 1Institut d'Embryologie du CNRS et du Collège de France, Nogent sur Marne. The EMBO Journal (1988)7:2775-2785https://doi.org/10.1002/j.1460-2075.1988.tb03132.x PDFDownload PDF of article text and main figures. ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinked InMendeleyWechatReddit Figures & Info We have cloned in a cosmid vector four DNA clusters covering 320 kb of the chicken MHC (B complex), including five class II (B-L) beta genes defining two related isotypic families. Additional B complex genes have been revealed using tissue-specific cDNA probes. A cosmid fragment has been used to isolate a cDNA for a class I (B-F) transcript. This transcript, that is by far the most divergent known member of the class I gene family, hybridized to six B-F genes present in the cosmids. One of the clusters was shown to contain two rRNA transcriptional units from the nucleolar organizer region (NOR), marking the telomeric boundary of the B complex. None of the other B complex genes hybridizes to, or has the transcriptional characteristics of mammalian MHC class II alpha or class III genes. The map we have obtained shows that the B complex does not contain well defined class I and class II regions since B-F and B-L beta genes are closely associated with unrelated genes. Moreover, class II beta genes are very closely linked to class I genes in two clusters, and to the NOR in a third one. Previous ArticleNext Article Volume 7Issue 91 September 1988In this issue RelatedDetailsLoading ..." @default.
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• W47407007 title "A molecular map of the chicken major histocompatibility complex: the class II beta genes are closely linked to the class I genes and the nucleolar organizer." @default.
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