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• W47469025 abstract "Advances in molecular and cellular biology have given us increased certainty in our descriptions of receptors and their associated transducer proteins, and help pharmacologists to document receptor stimulus-response pathways with increasing precision. However, in many cases, several concurrent interacting and branching pathways operate, resulting in a level of complexity that hinders understanding of the relative importance of those paths even in simple cellular systems. The inherent complexities of intact organs and whole animals compound those of the cellular level and, thus, it is doubly difficult to make a complete description of the overall stimulus-response pathways that might operate at those higher levels of organisation. Nonetheless, an attempt needs to be made because, from a therapeutic standpoint, the important pathways are those that operate in the relevant target organ under physiological and pathophysiological conditions. This chapter is a selective review of vascular stimulus-response mechanisms of α 1- and α 2-adrenoceptors and an attempt to integrate the observations from cellular and intact systems. α-Adrenoceptors are an ideal subject, because many studies explore and compare their coupling mechanisms, but this chapter is not intended to make a case for any special relationship between α 1- and α 2-adrenoceptors beyond their sharing of the physiological agonists norepinephrine and epinephrine. Most of the concepts aired in this review are also relevant to other receptor types in both vascular and non-vascular tissues, because the complications arising from intrinsic properties of vascular smooth muscle are likely to be analogous to complications that are important in many different tissues." @default.
• W47469025 created "2016-06-24" @default.
• W47469025 creator A5051162345 @default.
• W47469025 date "2000-01-01" @default.
• W47469025 modified "2023-09-27" @default.
• W47469025 title "Problems in Assigning Mechanisms: Reconciling the Molecular and Functional Pathways in α-Adrenoceptor-Mediated Vasoconstriction" @default.
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• W47469025 doi "https://doi.org/10.1007/978-3-642-57081-0_3" @default.
• W47469025 hasPublicationYear "2000" @default.
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