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• W47470443 abstract "Event Abstract Back to Event Comparison of Cognitive Vulnerability Indicators in Bipolar disorder (BD) and Schizophrenia (SZ) Anastasia-Tessa Christodoulou1* 1 Institute of Psychiatry, United Kingdom Background:Investigation of cognitive deficits in healthy individuals (No Axis I or II disorders) at high genetic risk for BD and SZ. Materials and Methods: 17 and 15 (BD-R and SZ-R) and 23 controls. They underwent assessment of Full Scale IQ (Wechsler Adult Intelligence Scale Revised, WAIS-R), verbal memory and learning (California Verbal Learning test, CVLT), working memory (N-back), inhibition and initiation (Hayling Sentence Completion Task, HSCT), verbal fluency (Controlled Oral Word Association, COWA) and tasks requiring switching between stimulus independent and orientated conditions. The Structured Clinical Interview for DSM-IV (SCID) confirmed the lack of Axis I and II disorders. Level of symptomatology was assessed with the Hamilton Depression Rating Scale (HDRS) and Young Mania Rating Scale (YMRS). Results: No difference was found in the IQ. Loss of inhibition was found for both SZ-R and BD-R (HSCT) who also underperformed compared to controls in short and long delay recall in the verbal learning and memory (CVLT). SZ-R made more intrusions and perseverations (CVLT). Both produced fewer words compared to controls whereas the SZ-R made more errors (COWA). The SZ-R had fewer correct responses (n-back) and failed to inhibit relatively fast erroneous responses, leading to errors but not reaction times (switching). Conclusions: Genetic predisposition to SZ may be mediated by dysfunction in the anterior and Ventral Prefrontal Cortex (VPFC) (BA45/47), Dorsal Prefrontal Cortex (DPFC) and posterior (BA9, 44, 46) areas of the inferior frontal gyrus, the right rostrolateral PFC (BA 10), right DPFC and bilateral superior parietal cortex and temporal networks. In BD-R impairment was limited in the VPFC (BA45/47) whereas the DPFC (BA9, 46) and related functions were preserved. SZ and BD share inhibition deficits associated with the VPFC whereas impairments in the frontotemporal networks and the DPFC may be associated with genetic predisposition to SZ. Conference: 41st European Brain and Behaviour Society Meeting, Rhodes Island, Greece, 13 Sep - 18 Sep, 2009. Presentation Type: Poster Presentation Topic: Poster presentations Citation: Christodoulou A (2009). Comparison of Cognitive Vulnerability Indicators in Bipolar disorder (BD) and Schizophrenia (SZ). Conference Abstract: 41st European Brain and Behaviour Society Meeting. doi: 10.3389/conf.neuro.08.2009.09.114 Copyright: The abstracts in this collection have not been subject to any Frontiers peer review or checks, and are not endorsed by Frontiers. They are made available through the Frontiers publishing platform as a service to conference organizers and presenters. The copyright in the individual abstracts is owned by the author of each abstract or his/her employer unless otherwise stated. Each abstract, as well as the collection of abstracts, are published under a Creative Commons CC-BY 4.0 (attribution) licence (https://creativecommons.org/licenses/by/4.0/) and may thus be reproduced, translated, adapted and be the subject of derivative works provided the authors and Frontiers are attributed. For Frontiers’ terms and conditions please see https://www.frontiersin.org/legal/terms-and-conditions. Received: 08 Jun 2009; Published Online: 08 Jun 2009. * Correspondence: Anastasia-Tessa Christodoulou, Institute of Psychiatry, London, United Kingdom, tessa_christodoulou@hotmail.com Login Required This action requires you to be registered with Frontiers and logged in. To register or login click here. Abstract Info Abstract The Authors in Frontiers Anastasia-Tessa Christodoulou Google Anastasia-Tessa Christodoulou Google Scholar Anastasia-Tessa Christodoulou PubMed Anastasia-Tessa Christodoulou Related Article in Frontiers Google Scholar PubMed Abstract Close Back to top Javascript is disabled. Please enable Javascript in your browser settings in order to see all the content on this page." @default.
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• W47470443 date "2009-01-01" @default.
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• W47470443 title "Comparison of Cognitive Vulnerability Indicators in Bipolar disorder (BD) and Schizophrenia (SZ)" @default.
• W47470443 doi "https://doi.org/10.3389/conf.neuro.08.2009.09.114" @default.
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