Matches in SemOpenAlex for { <https://semopenalex.org/work/W47470830> ?p ?o ?g. }
Showing items 1 to 76 of
76
with 100 items per page.
- W47470830 abstract "Introduction: Ectopic fat depots may play a role in obesity-mediated cardiovascular disease (CVD). We tested the association of several distinct fat depots and incident CVD in an asymptomatic community-based sample. Methods: Participants from the Framingham Heart Study (n=3086, 49% women, mean age 50.2 years, free of CVD at baseline) underwent volumetric assessment of multiple fat depots using multidetector computed tomography from 2002–2005, and were followed longitudinally for CVD events. Fat depots included subcutaneous adipose tissue (SAT), visceral adipose tissue (VAT), pericardial adipose tissue, intra-thoracic adipose tissue and thoracic periaortic adipose tissue (TAT). Adipose volumes were standardized within sex to a mean of 0 and a standard deviation of 1. Cardiovascular events included coronary heart disease (myocardial infarction, coronary insufficiency or angina), cerebrovascular disease (stroke or transient ischemic attack), intermittent claudication, heart failure or CVD death. Using Cox proportional hazards regression models, we examined the association of each fat depot with the risk of CVD after adjustment for age, sex, systolic blood pressure, hypertension treatment, diabetes, total cholesterol, high-density lipoprotein cholesterol, smoking, and then additionally for BMI. We additionally examined the association of pericardial fat and incident coronary heart disease. Results: During a mean follow-up of 4.7 years, 90 CVD events occurred. After multivariable adjustment, VAT, VAT/SAT ratio, intra-thoracic fat and TAT were significantly associated with incident CVD events. The hazard ratios (95% confidence intervals) per each standard deviation higher were 1.37 (1.10–1.71, p=0.006 [VAT]), 1.30 (1.05–1.60, p=0.02 [VAT/SAT ratio]), 1.28 (1.03–1.59, p=0.03 [intra-thoracic fat]), and 1.30 (1.03–1.67, p=0.03 [TAT]), respectively. We observed no association between BMI (HR 1.15, 0.92–1.43, p=0.21), SAT (HR 1.13, 0.90–1.42, p=0.28) or pericardial fat (HR 1.14, 0.95–1.37, p=0.15) and incident CVD. After additional adjustment for BMI, VAT, VAT/SAT ratio and TAT remained significantly associated with incident CVD events [HR 1.44 (1.08–1.92, p=0.01 [VAT]), 1.34 (1.08–1.65, p=0.007 [VAT/SAT ratio]), and 1.31 (1.03–1.67, p=0.03 [TAT])], respectively. Pericardial fat was also not associated with incident coronary heart disease, even when limiting our events to myocardial infarction or coronary heart disease death (HR 0.97, p=0.81). Conclusion: Several distinct ectopic fat depots, including VAT, VAT/SAT ratio, intra-thoracic fat, and TAT, but not generalized obesity, are significantly associated with CVD events after adjustment for risk factors in our community-based sample. These findings support the growing recognition of several potentially pathogenic ectopic fat depots." @default.
- W47470830 created "2016-06-24" @default.
- W47470830 creator A5008596377 @default.
- W47470830 creator A5024590816 @default.
- W47470830 creator A5034086399 @default.
- W47470830 creator A5038663858 @default.
- W47470830 creator A5056798958 @default.
- W47470830 date "2012-03-13" @default.
- W47470830 modified "2023-10-18" @default.
- W47470830 title "Abstract 025: Multidetector Computed Tomography Adipose Tissue Depots and Incident Cardiovascular Disease" @default.
- W47470830 doi "https://doi.org/10.1161/circ.125.suppl_10.a025" @default.
- W47470830 hasPublicationYear "2012" @default.
- W47470830 type Work @default.
- W47470830 sameAs 47470830 @default.
- W47470830 citedByCount "0" @default.
- W47470830 crossrefType "journal-article" @default.
- W47470830 hasAuthorship W47470830A5008596377 @default.
- W47470830 hasAuthorship W47470830A5024590816 @default.
- W47470830 hasAuthorship W47470830A5034086399 @default.
- W47470830 hasAuthorship W47470830A5038663858 @default.
- W47470830 hasAuthorship W47470830A5056798958 @default.
- W47470830 hasConcept C111815664 @default.
- W47470830 hasConcept C11783203 @default.
- W47470830 hasConcept C126322002 @default.
- W47470830 hasConcept C127413603 @default.
- W47470830 hasConcept C164705383 @default.
- W47470830 hasConcept C171089720 @default.
- W47470830 hasConcept C207103383 @default.
- W47470830 hasConcept C2777910003 @default.
- W47470830 hasConcept C2778198053 @default.
- W47470830 hasConcept C2778213512 @default.
- W47470830 hasConcept C2778425758 @default.
- W47470830 hasConcept C2779134260 @default.
- W47470830 hasConcept C2780645631 @default.
- W47470830 hasConcept C44249647 @default.
- W47470830 hasConcept C500558357 @default.
- W47470830 hasConcept C50382708 @default.
- W47470830 hasConcept C71924100 @default.
- W47470830 hasConcept C78519656 @default.
- W47470830 hasConceptScore W47470830C111815664 @default.
- W47470830 hasConceptScore W47470830C11783203 @default.
- W47470830 hasConceptScore W47470830C126322002 @default.
- W47470830 hasConceptScore W47470830C127413603 @default.
- W47470830 hasConceptScore W47470830C164705383 @default.
- W47470830 hasConceptScore W47470830C171089720 @default.
- W47470830 hasConceptScore W47470830C207103383 @default.
- W47470830 hasConceptScore W47470830C2777910003 @default.
- W47470830 hasConceptScore W47470830C2778198053 @default.
- W47470830 hasConceptScore W47470830C2778213512 @default.
- W47470830 hasConceptScore W47470830C2778425758 @default.
- W47470830 hasConceptScore W47470830C2779134260 @default.
- W47470830 hasConceptScore W47470830C2780645631 @default.
- W47470830 hasConceptScore W47470830C44249647 @default.
- W47470830 hasConceptScore W47470830C500558357 @default.
- W47470830 hasConceptScore W47470830C50382708 @default.
- W47470830 hasConceptScore W47470830C71924100 @default.
- W47470830 hasConceptScore W47470830C78519656 @default.
- W47470830 hasIssue "suppl_10" @default.
- W47470830 hasLocation W474708301 @default.
- W47470830 hasOpenAccess W47470830 @default.
- W47470830 hasPrimaryLocation W474708301 @default.
- W47470830 hasRelatedWork W1852347903 @default.
- W47470830 hasRelatedWork W1988158851 @default.
- W47470830 hasRelatedWork W202416730 @default.
- W47470830 hasRelatedWork W2104371670 @default.
- W47470830 hasRelatedWork W2155913505 @default.
- W47470830 hasRelatedWork W2213857236 @default.
- W47470830 hasRelatedWork W2265227815 @default.
- W47470830 hasRelatedWork W2298736515 @default.
- W47470830 hasRelatedWork W2351765193 @default.
- W47470830 hasRelatedWork W2979861098 @default.
- W47470830 hasVolume "125" @default.
- W47470830 isParatext "false" @default.
- W47470830 isRetracted "false" @default.
- W47470830 magId "47470830" @default.
- W47470830 workType "article" @default.