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• W47487143 abstract "The majority of Alzheimer patients is of late onset and with unknown etiology. However, several risk factors have been discussed among which age is a most important one with respect to sporadic Alzheimer type dementia (SDAT). Age includes changes in brain glucose/energy metabolism, in both insulin and acetylcholine signal transduction and in membrane function to name the functionally most important ones. Variations in these parameters can form the basis for ongoing changes in terms of the principle of self-organized critically inducing catastrophic i.e. disease processes. Subsequent abnormalities at the cellular and molecular levels may develop including the formation of both amyloid plaques and neurofibrillary tangles." @default.
• W47487143 created "2016-06-24" @default.
• W47487143 creator A5015825952 @default.
• W47487143 date "1998-01-01" @default.
• W47487143 modified "2023-09-25" @default.
• W47487143 title "Risk factors for Azheimer’s disease during aging. Impacts of glucose/energy metabolism" @default.
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• W47487143 doi "https://doi.org/10.1007/978-3-7091-7508-8_18" @default.
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