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- W47563809 abstract "The effects of norepinephrine (NOR) infusion on hemodynamic alterations induced with sedative doses of acepromazine (ACP) were evaluated. Infusion of NOR at 1 μg/kg body weight (BW)/minute for 15 min was administered to 5 standing horses 45 min (T45) after intravenous injection of ACP at 0.1 mg/kg BW. Systolic arterial blood pressure (SAP) and hemodynamic parameters were evaluated on the median artery. Parameters were evaluated every 5 min from 45 to 65 min (T65) at 75 (T75), 90 (T90), and 105 (T105) minutes after ACP administration, and the vessel's surface (SURF), diameter (DIAM), circumference (CIRC), peak systolic velocity (PSV), end diastolic velocity (EDV), mean velocity (MV), volumetric flow (VF) and resistivity index (RI) of the flow were calculated. Acepromazine induced hypotension and vasodilation with a significant rise in SURF, DIAM, CIRC, PSV, EDV, MV, and VF and a reduction in RI and SAP, which were significantly counteracted from T50 to T60 for EDV, VF, MV and RI, and to T65 for SAP, from T50 to T90 for CIRC and SURF and to T60 for DIAM. These findings demonstrate that a 1 μg/kg BW/minute NOR infusion can reverse ACP's vasodilatory effects, restoring hemodynamic parameters and blood pressure in horses. Évaluation d’altérations hémodynamiques induites par l’acépromazine et inversion par une infusion de norépinéphrine chez des chevaux debout. Les effets d’une infusion de norépinéphrine (NOR) sur les altérations hémodynamiques induites avec des doses sédatives d’acépromazine (ACP) ont été évalués. Une infusion de NOR à 1 μg/kg poids corporel (PC)/minute pendant 15 minutes a été administrée à 5 chevaux debout 45 minutes (T45) après une injection intraveineuse d’ACP à 0,1 mg/kg PC. La tension artérielle systolique (TAS) et les paramètres hémodynamiques ont été évalués sur l’artère médiane. Les paramètres ont été évalués toutes les 5 minutes, de 45 à 65 minutes (T65), puis 75 (T75), 90 (T90) et 105 (T105) minutes après l’administration d’ACP et la surface (SURF), le diamètre (DIAM), la circonférence (CIRC), le pic de vélocité systolique (PVS), la vélocité en fin de diastole (VFD), la vélocité moyenne (VM) et l’écoulement volumétrique (EV) du vaisseau ainsi que l’indice de résistivité (IR) du débit ont été calculés. L’hypotension et la vasodilatation induites par l’acépromazine causant une hausse significative de SURF, de DIAM, de CIRC, de PVS, d’EV, de VM et de EV ainsi qu’une réduction d’IR et de TAS ont été significativement compensées de T50 à T60 pour EDV, VF, MV et RI, à T65 pour SAP, de T50 à T90 pour CIRC et SURF et à T60 pour DIAM. Ces constatations démontrent qu’une infusion de 1 μg/kg PC/minute NOR peut inverser les effets vasodilatoires d’ACP, rétablissant les paramètres hémodynamiques et la tension artérielle chez les chevaux.(Traduit par Isabelle Vallières)." @default.
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- W47563809 date "2013-02-01" @default.
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- W47563809 title "Evaluation of acepromazine-induced hemodynamic alterations and reversal with norepinephrine infusion in standing horses." @default.
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