Matches in SemOpenAlex for { <https://semopenalex.org/work/W47668600> ?p ?o ?g. }
Showing items 1 to 72 of
72
with 100 items per page.
- W47668600 endingPage "1181" @default.
- W47668600 startingPage "1179" @default.
- W47668600 abstract "The effect of insulin administration on bone formation was investigated in the femoral diaphysis of rats with skeletal unloading. When the femoral-diaphyseal tissues from normal rats were cultured in the presence of insulin (10(-9) and 10(-8) M) for 48 h, the hormone produced a significant increase of alkaline phosphatase activity, collagen, deoxyribonucleic acid (DNA) and calcium contents in the bone tissues, indicating that it has a direct stimulatory effect on bone formation. Moreover, when normal rats received a subcutaneous administration of insulin (5.0 IU/100 g body weight) 5 times at 24-h intervals, the hormone caused a significant increase of alkaline phosphatase activity, DNA and calcium contents in the femoral diaphysis. Those increases were not seen by insulin administration to the skeletal-unloading rats with hindlimb hang for 4 d. The present results indicate that the stimulatory effect of insulin on bone formation is lost by skeletal unloading. The finding further supports the view that insulin impairment plays an important role in the deterioration of bone formation by microgravity." @default.
- W47668600 created "2016-06-24" @default.
- W47668600 creator A5017811548 @default.
- W47668600 creator A5051437482 @default.
- W47668600 creator A5071207129 @default.
- W47668600 date "1993-01-01" @default.
- W47668600 modified "2023-10-17" @default.
- W47668600 title "Effect of Insulin Administration on Bone Formation Is Impaired in Rats with Skeletal Unloading." @default.
- W47668600 cites W1566830427 @default.
- W47668600 doi "https://doi.org/10.1248/bpb.16.1179" @default.
- W47668600 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/8312880" @default.
- W47668600 hasPublicationYear "1993" @default.
- W47668600 type Work @default.
- W47668600 sameAs 47668600 @default.
- W47668600 citedByCount "13" @default.
- W47668600 countsByYear W476686002014 @default.
- W47668600 countsByYear W476686002015 @default.
- W47668600 crossrefType "journal-article" @default.
- W47668600 hasAuthorship W47668600A5017811548 @default.
- W47668600 hasAuthorship W47668600A5051437482 @default.
- W47668600 hasAuthorship W47668600A5071207129 @default.
- W47668600 hasBestOaLocation W476686001 @default.
- W47668600 hasConcept C126322002 @default.
- W47668600 hasConcept C134018914 @default.
- W47668600 hasConcept C141071460 @default.
- W47668600 hasConcept C160160445 @default.
- W47668600 hasConcept C181199279 @default.
- W47668600 hasConcept C185592680 @default.
- W47668600 hasConcept C2778951355 @default.
- W47668600 hasConcept C2779306644 @default.
- W47668600 hasConcept C2780554211 @default.
- W47668600 hasConcept C51738704 @default.
- W47668600 hasConcept C519063684 @default.
- W47668600 hasConcept C55493867 @default.
- W47668600 hasConcept C71315377 @default.
- W47668600 hasConcept C71924100 @default.
- W47668600 hasConceptScore W47668600C126322002 @default.
- W47668600 hasConceptScore W47668600C134018914 @default.
- W47668600 hasConceptScore W47668600C141071460 @default.
- W47668600 hasConceptScore W47668600C160160445 @default.
- W47668600 hasConceptScore W47668600C181199279 @default.
- W47668600 hasConceptScore W47668600C185592680 @default.
- W47668600 hasConceptScore W47668600C2778951355 @default.
- W47668600 hasConceptScore W47668600C2779306644 @default.
- W47668600 hasConceptScore W47668600C2780554211 @default.
- W47668600 hasConceptScore W47668600C51738704 @default.
- W47668600 hasConceptScore W47668600C519063684 @default.
- W47668600 hasConceptScore W47668600C55493867 @default.
- W47668600 hasConceptScore W47668600C71315377 @default.
- W47668600 hasConceptScore W47668600C71924100 @default.
- W47668600 hasIssue "11" @default.
- W47668600 hasLocation W476686001 @default.
- W47668600 hasLocation W476686002 @default.
- W47668600 hasOpenAccess W47668600 @default.
- W47668600 hasPrimaryLocation W476686001 @default.
- W47668600 hasRelatedWork W1983641721 @default.
- W47668600 hasRelatedWork W1995945960 @default.
- W47668600 hasRelatedWork W2026226896 @default.
- W47668600 hasRelatedWork W2032033851 @default.
- W47668600 hasRelatedWork W2041678535 @default.
- W47668600 hasRelatedWork W2066345847 @default.
- W47668600 hasRelatedWork W2089387278 @default.
- W47668600 hasRelatedWork W2095179743 @default.
- W47668600 hasRelatedWork W2130904138 @default.
- W47668600 hasRelatedWork W2748952813 @default.
- W47668600 hasVolume "16" @default.
- W47668600 isParatext "false" @default.
- W47668600 isRetracted "false" @default.
- W47668600 magId "47668600" @default.
- W47668600 workType "article" @default.