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- W47733356 abstract "Abstract By interaction of streptococcal erythrogenic toxins A and B with chick embryo fibroblasts and human amnion (FL) cells an antiviral interferon-like factor was secreted. It inhibited the replication of vesicular stomatitis, vaccinia and Mengo viruses. The streptococcal toxin type B was 50 times more cytotoxic for both cell cultures in comparison with streptococcal toxin A. The maximum tolerated doses of the two types of streptococcal toxins induced approximately the same antiviral protection effect. The production curve of the antiviral factor showed a maximum at the 12 th hour after incubation at 37°C with graduate decrease up to the 24 th hour using a 6 hours induction time. The interferons induced by the streptococcal erythrogenic toxins A and B were thermostable at 56°C for 30 min and were partially destroyed at pH 2 as tested against Mengo virus in FL cells. The antiviral effect could be reversed by addition of streptococcal erythrogenic toxin A at the maximum tolerated dose simultaneously with the glycosylating inhibitors strepto-virudin and D-glucosamine by 90 and 100 per cent, respectively." @default.
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- W47733356 date "1982-09-01" @default.
- W47733356 modified "2023-10-12" @default.
- W47733356 title "Induktion von immuninterferon durch erythrogene toxine A und B des streptococcus pyogenes" @default.
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- W47733356 doi "https://doi.org/10.1016/s0174-3031(82)80023-1" @default.
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