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- W47994712 abstract "Our studies demonstrated dietary butyrate (SB) and resistant starch (RS) reduced body fat. SB absorbed in upper gut acts directly on peripheral tissues. RS fermented to butyrate in the lower gut is associated with increased PYY and GLP-1 acting indirectly through an endocrine mechanism. Ultimately, mechanisms converge at peripheral tissues. Forty (8 wk) male SD rats were fed 4 diets (n=15; 3.2 kcal/g) for 12 wk: control (C), RS (28%), SB (3.2%), and SB + RS. Results were considered significant at p<0.05; data analyzed by 2 × 2 factorial. There were significant main effects for reduction in abdominal fat pads for SB and RS, e.g. epididymal (g and % bw): C, 5.8, 1.44; SB, 4.8, 1.3; RS, 4.8, 1.3; and SB + RS, 4.0±0.2, 1.1±0.05. Although the SB + RS fat level was the numerically lowest there was not a significant interaction indicating a possible “saturation” of the mechanism at the high doses used. There was also a significant main effect of RS for increased plasma PYY and GLP-1 confirming the difference in the initial mechanism; and a significant interaction between SB and RS for the two hormones. The SB + RS group had lower PYY and GLP-1 than RS with a speculated down-regulation of the hormones possibly due again to the “saturation” of the mechanism. Future studies will focus on lower doses to determine if the combination can promote similar fat reductions as with the individual high doses of SB or RS. Funding: LSU AgCenter and National Starch." @default.
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- W47994712 date "2010-04-01" @default.
- W47994712 modified "2023-09-27" @default.
- W47994712 title "Combining resistant starch and sodium butyrate for reducing body fat in rats" @default.
- W47994712 doi "https://doi.org/10.1096/fasebj.24.1_supplement.95.5" @default.
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