FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W48054089> ?p ?o ?g. }

• W48054089 endingPage "339" @default.
• W48054089 startingPage "327" @default.
• W48054089 abstract "In vivo studies have shown that thyrotropin regulates thyroid growth and function. How TSH is able to exert these dramatic effects is not clear. The last decade has seen such refinements in cell culture systems that this question can finally be addressed. The major advance in cell culture technology has been the removal of serum from the culture medium of primary cultures of thyroid cells released from tissues. Serum can be replaced by a cocktail of hormones and other factors which have been determined empirically to be essential for the maintenance of most cells in culture.1 This chemically-defined medium permits researchers to add hormones both individually and in combination to examine direct, cooperative, and indirect interactions between them. Another unanticipated benefit from serum-free culture of thyroid cells has been that thyroid cell conditioned medium has been found to contain several proteins of potential biological importance.2–5 This finding has opened up a new area examining potential endocrine functions other than thyroid hormone production for the thyroid. Alternatively, these newly discovered products could be for autocrine or paracrine use. In this brief review we shall discuss the direct ways in which TSH is thought to regulate thyroid growth and function and how TSH interacts with other hormones and growth factors to influence these parameters. We shall examine the intracellular pathways thought to be activated by TSH, growth factors and by agents known to be capable of discretely activating second messengers of some partially defined intracellular pathways. We shall use as a model system data we have obtained with the sheep thyroid cell culture system. This culture system differs from FRTL5, dog and human thyroid cells in culture because cells reorganize to form 3D follicles6 and synthesize and secrete physiologic quantities of thyroid hormones.7 KeywordsThyroid CellInositol TrisphosphateFRTL5 CellHuman Thyroid CellThyroid GrowthThese keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves." @default.
• W48054089 created "2016-06-24" @default.
• W48054089 creator A5009389483 @default.
• W48054089 creator A5050448142 @default.
• W48054089 date "1989-01-01" @default.
• W48054089 modified "2023-09-25" @default.
• W48054089 title "Integrated Regulation of Growth and of Function" @default.
• W48054089 cites W1964614589 @default.
• W48054089 cites W1968260666 @default.
• W48054089 cites W1974036045 @default.
• W48054089 cites W1978966292 @default.
• W48054089 cites W1982076751 @default.
• W48054089 cites W1986236392 @default.
• W48054089 cites W1988803304 @default.
• W48054089 cites W1994501356 @default.
• W48054089 cites W1997885037 @default.
• W48054089 cites W2000935451 @default.
• W48054089 cites W2006323812 @default.
• W48054089 cites W2009928329 @default.
• W48054089 cites W2016096247 @default.
• W48054089 cites W2018751358 @default.
• W48054089 cites W2020599283 @default.
• W48054089 cites W2022822844 @default.
• W48054089 cites W2024678464 @default.
• W48054089 cites W2032493713 @default.
• W48054089 cites W2042843602 @default.
• W48054089 cites W2044090640 @default.
• W48054089 cites W2045208557 @default.
• W48054089 cites W2050842963 @default.
• W48054089 cites W2052254287 @default.
• W48054089 cites W2059080130 @default.
• W48054089 cites W2071244314 @default.
• W48054089 cites W2080568630 @default.
• W48054089 cites W2082775739 @default.
• W48054089 cites W2087823365 @default.
• W48054089 cites W2106516118 @default.
• W48054089 cites W2153563435 @default.
• W48054089 cites W2166086645 @default.
• W48054089 cites W2435689619 @default.
• W48054089 doi "https://doi.org/10.1007/978-1-4757-2058-7_13" @default.
• W48054089 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/2699972" @default.
• W48054089 hasPublicationYear "1989" @default.
• W48054089 type Work @default.
• W48054089 sameAs 48054089 @default.
• W48054089 citedByCount "4" @default.
• W48054089 crossrefType "book-chapter" @default.
• W48054089 hasAuthorship W48054089A5009389483 @default.
• W48054089 hasAuthorship W48054089A5050448142 @default.
• W48054089 hasConcept C128240485 @default.
• W48054089 hasConcept C134018914 @default.
• W48054089 hasConcept C14036430 @default.
• W48054089 hasConcept C170493617 @default.
• W48054089 hasConcept C185592680 @default.
• W48054089 hasConcept C2777886399 @default.
• W48054089 hasConcept C2779571634 @default.
• W48054089 hasConcept C2993291352 @default.
• W48054089 hasConcept C526584372 @default.
• W48054089 hasConcept C54355233 @default.
• W48054089 hasConcept C55493867 @default.
• W48054089 hasConcept C62112901 @default.
• W48054089 hasConcept C71315377 @default.
• W48054089 hasConcept C7876069 @default.
• W48054089 hasConcept C79879829 @default.
• W48054089 hasConcept C81885089 @default.
• W48054089 hasConcept C86803240 @default.
• W48054089 hasConcept C95444343 @default.
• W48054089 hasConceptScore W48054089C128240485 @default.
• W48054089 hasConceptScore W48054089C134018914 @default.
• W48054089 hasConceptScore W48054089C14036430 @default.
• W48054089 hasConceptScore W48054089C170493617 @default.
• W48054089 hasConceptScore W48054089C185592680 @default.
• W48054089 hasConceptScore W48054089C2777886399 @default.
• W48054089 hasConceptScore W48054089C2779571634 @default.
• W48054089 hasConceptScore W48054089C2993291352 @default.
• W48054089 hasConceptScore W48054089C526584372 @default.
• W48054089 hasConceptScore W48054089C54355233 @default.
• W48054089 hasConceptScore W48054089C55493867 @default.
• W48054089 hasConceptScore W48054089C62112901 @default.
• W48054089 hasConceptScore W48054089C71315377 @default.
• W48054089 hasConceptScore W48054089C7876069 @default.
• W48054089 hasConceptScore W48054089C79879829 @default.
• W48054089 hasConceptScore W48054089C81885089 @default.
• W48054089 hasConceptScore W48054089C86803240 @default.
• W48054089 hasConceptScore W48054089C95444343 @default.
• W48054089 hasLocation W480540891 @default.
• W48054089 hasLocation W480540892 @default.
• W48054089 hasOpenAccess W48054089 @default.
• W48054089 hasPrimaryLocation W480540891 @default.
• W48054089 hasRelatedWork W123308499 @default.
• W48054089 hasRelatedWork W1968299395 @default.
• W48054089 hasRelatedWork W2021841321 @default.
• W48054089 hasRelatedWork W2067037639 @default.
• W48054089 hasRelatedWork W2392571820 @default.
• W48054089 hasRelatedWork W248557187 @default.
• W48054089 hasRelatedWork W2548132282 @default.
• W48054089 hasRelatedWork W2740301186 @default.
• W48054089 hasRelatedWork W3025102417 @default.
• W48054089 hasRelatedWork W3027847640 @default.

• next