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- W48064413 abstract "Growth hormone (GH) synthesis and release is regulated by two hypothalamic peptides: somatostatin, which inhibits GH secretion, and growth hormone-releasing hormone (GHRH), which stimulates its release. Although somatostatin was the first to be identified in 1973 (1), the presence of a hypothalamic GH stimulating substance had been predicted in 1960 from rodent studies in which hypothalamic lesions induced growth impairment (2). However, because of methodological problems, particularly the loss of biological activity during purification, GHRH proved difficult to isolate. It was not until 1982 that GHRH was isolated from two separate pancreatic tumors obtained from individuals who presented with the clinical features of acromegaly (3,4). The finding that GHRH mRNA and peptides isolated from pancreas were identical to those produced endogenously by the hypothalamus (5,6), opened the door to a wealth of new discoveries. These have led to advances in understanding the transcriptional and translational regulation of the GHRH gene, characterization of the GHRH gene products, understanding the role of GHRH in regulating GH secretion, identification of the GHRH receptor and the discovery of GHRH receptor mutations in mice, and humans. In this chapter, these advances will be reviewed." @default.
- W48064413 created "2016-06-24" @default.
- W48064413 creator A5004483943 @default.
- W48064413 creator A5081694899 @default.
- W48064413 date "1999-01-01" @default.
- W48064413 modified "2023-09-26" @default.
- W48064413 title "Growth Hormone Releasing Hormone" @default.
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