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- W48097231 abstract "Only 25% of patients presenting for allogeneic bone marrow transplantation will have a sibling who is an antigenically matched potential donor (1). The use of alternative stem cell sources such as volunteer unrelated donors, mismatched related donors, cord blood, and placental blood has increased to meet the demands imposed by the limited number of matched sibling donors (2-4). As antigenic diversity between donor and host increases, so does the risk of graft versus host disease (GvHD) and graft rejection. Manipulations of the stem cells to reduce the risk of GvHD, such as T-cell depletion, lead to increased graft rejection and relapse among patients with malignancies (5-9). The risk of GvHD or rejection increases from 20% with a matched sibling donor to as high as 60% for a matched unrelated donor or over 70% for a mismatched unrelated donor (10-12). An important goal in extending the range of alternative donor is to achieve immunologic balance between donor and host T-cells and produce stable donor-derived hematopoiesis post-transplant." @default.
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- W48097231 date "1999-01-01" @default.
- W48097231 modified "2023-09-26" @default.
- W48097231 title "Clinical Use of Irradiated Donor Lymphocytes in Bone Marrow Transplantation" @default.
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- W48097231 doi "https://doi.org/10.1007/978-1-4615-4987-1_12" @default.
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