Matches in SemOpenAlex for { <https://semopenalex.org/work/W4821093> ?p ?o ?g. }
- W4821093 abstract "This chapter reviews some of the work that has been performed in animal models of CNS diseases, where transplanted neural stem cells (NSCs) have mediated a therapeutic effect. Despite the presence of endogenous NSCs in the mammalian brain, it is recognized that intrinsic “self-repair” activity for the most devastating of injuries is inadequate or ineffective. This poor “regenerative” ability, particularly in the adult CNS, may be because of the limited number and restricted location of native NSCs and/or limitations imposed by the surrounding microenvironment, which may not be supportive or instructive for neuronal differentiation. Several transplantation experiments have suggested that neurogenic cues are transiently elaborated during degenerative processes and that exogenous NSCs are able to sense, home in, and respond appropriately. Neural stem cells display extensive tropism for pathology in an adult brain and can express bioactive genes within such pathological situations: evidence from intracranial gliomas. NSCs migrate extensively throughout a brain tumor mass in vivo and “trail” advancing tumor cells. A major requirement for the better use of NSCs is a better understanding of the pathophysiology of the diseases to be targeted—that is, knowing what aspects require repair and which cell type or types require replacement or rescue. A better understanding of fundamental NSC biology is required before human NSCs can be transplanted efficaciously in true clinical settings." @default.
- W4821093 created "2016-06-24" @default.
- W4821093 creator A5004180020 @default.
- W4821093 creator A5004989258 @default.
- W4821093 creator A5010524054 @default.
- W4821093 creator A5023713351 @default.
- W4821093 creator A5037419429 @default.
- W4821093 creator A5044148849 @default.
- W4821093 creator A5071406969 @default.
- W4821093 creator A5080524118 @default.
- W4821093 creator A5083475763 @default.
- W4821093 creator A5089980476 @default.
- W4821093 date "2013-01-01" @default.
- W4821093 modified "2023-09-23" @default.
- W4821093 title "Neural Stem Cells – Therapeutic Applications in Neurodegenerative Diseases" @default.
- W4821093 cites W1001099587 @default.
- W4821093 cites W1606173244 @default.
- W4821093 cites W1718365317 @default.
- W4821093 cites W1906370123 @default.
- W4821093 cites W1936342032 @default.
- W4821093 cites W1969365417 @default.
- W4821093 cites W1980441719 @default.
- W4821093 cites W1987107175 @default.
- W4821093 cites W1991556375 @default.
- W4821093 cites W1996822067 @default.
- W4821093 cites W2001627351 @default.
- W4821093 cites W2013766233 @default.
- W4821093 cites W2015500392 @default.
- W4821093 cites W2020745529 @default.
- W4821093 cites W2031324202 @default.
- W4821093 cites W2031874070 @default.
- W4821093 cites W2033410250 @default.
- W4821093 cites W2036403129 @default.
- W4821093 cites W2037681653 @default.
- W4821093 cites W2050142708 @default.
- W4821093 cites W2054438521 @default.
- W4821093 cites W2064496329 @default.
- W4821093 cites W2073450010 @default.
- W4821093 cites W2077220534 @default.
- W4821093 cites W2084652820 @default.
- W4821093 cites W2089735370 @default.
- W4821093 cites W2090024896 @default.
- W4821093 cites W2094505884 @default.
- W4821093 cites W2094613247 @default.
- W4821093 cites W2101736392 @default.
- W4821093 cites W2102426962 @default.
- W4821093 cites W2119739306 @default.
- W4821093 cites W2123450039 @default.
- W4821093 cites W2125189150 @default.
- W4821093 cites W2130486296 @default.
- W4821093 cites W2131608302 @default.
- W4821093 cites W2143393619 @default.
- W4821093 cites W2148593514 @default.
- W4821093 cites W2152489651 @default.
- W4821093 cites W2152548188 @default.
- W4821093 cites W2162036219 @default.
- W4821093 cites W2163129647 @default.
- W4821093 cites W2164986141 @default.
- W4821093 doi "https://doi.org/10.1016/b978-0-12-385942-6.00061-5" @default.
- W4821093 hasPublicationYear "2013" @default.
- W4821093 type Work @default.
- W4821093 sameAs 4821093 @default.
- W4821093 citedByCount "0" @default.
- W4821093 crossrefType "book-chapter" @default.
- W4821093 hasAuthorship W4821093A5004180020 @default.
- W4821093 hasAuthorship W4821093A5004989258 @default.
- W4821093 hasAuthorship W4821093A5010524054 @default.
- W4821093 hasAuthorship W4821093A5023713351 @default.
- W4821093 hasAuthorship W4821093A5037419429 @default.
- W4821093 hasAuthorship W4821093A5044148849 @default.
- W4821093 hasAuthorship W4821093A5071406969 @default.
- W4821093 hasAuthorship W4821093A5080524118 @default.
- W4821093 hasAuthorship W4821093A5083475763 @default.
- W4821093 hasAuthorship W4821093A5089980476 @default.
- W4821093 hasConcept C136834591 @default.
- W4821093 hasConcept C141071460 @default.
- W4821093 hasConcept C1491633281 @default.
- W4821093 hasConcept C169760540 @default.
- W4821093 hasConcept C189014844 @default.
- W4821093 hasConcept C203014093 @default.
- W4821093 hasConcept C2522874641 @default.
- W4821093 hasConcept C28328180 @default.
- W4821093 hasConcept C2911091166 @default.
- W4821093 hasConcept C35693153 @default.
- W4821093 hasConcept C54355233 @default.
- W4821093 hasConcept C71924100 @default.
- W4821093 hasConcept C86803240 @default.
- W4821093 hasConcept C95444343 @default.
- W4821093 hasConceptScore W4821093C136834591 @default.
- W4821093 hasConceptScore W4821093C141071460 @default.
- W4821093 hasConceptScore W4821093C1491633281 @default.
- W4821093 hasConceptScore W4821093C169760540 @default.
- W4821093 hasConceptScore W4821093C189014844 @default.
- W4821093 hasConceptScore W4821093C203014093 @default.
- W4821093 hasConceptScore W4821093C2522874641 @default.
- W4821093 hasConceptScore W4821093C28328180 @default.
- W4821093 hasConceptScore W4821093C2911091166 @default.
- W4821093 hasConceptScore W4821093C35693153 @default.
- W4821093 hasConceptScore W4821093C54355233 @default.
- W4821093 hasConceptScore W4821093C71924100 @default.