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• W48259134 abstract "In an attempt to determine whether the production and synthesis of testosterone (T) by the testis is impaired by the cryptorchid state, the ability of the cryptorchid rat testis to form T was assessed at various time periods into adulthood after the surgical induction of cryptorchidism in the newborn period. The intratesticular T content of the descended testis rose from 0.3 ng/testis at 14 days of age to 71.2 ng/testis at adulthood (day 56); whereas in the cryptorchid testis, the values were 0.4 ng/testis and 2.0 ng/testis, respectively, at the same ages (P < 0.001). For determination of the site of inhibition of T biosynthesis in the cryptorchid testis, the enzymatic activities (17α-hydroxylase, 17,20-desmolase, and 17β-hydroxysteroid dehydrogenase) in the ∆4T biosynthetic pathway were measured. All these enzyme activities in the cryptorchid testis were inhibited at 56 days of age by about 80% when compared with the descended testis (P < 0.01). These data suggest that cryptorchidism exerts a deleterious effect on the ability of the Leydig cells to synthesize T and may in part explain the abnormal morphology and resultant infertility seen in patients with cryptorchidism." @default.
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• W48259134 date "1985-07-01" @default.
• W48259134 modified "2023-09-26" @default.
• W48259134 title "Impaired testosterone biosynthesis in cryptorchidism" @default.
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• W48259134 doi "https://doi.org/10.1016/s0015-0282(16)48689-9" @default.
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