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- W48347913 abstract "The metabolism of ethanol in humans occurs mainly through oxidative pathways. Enzymes that can catalyze the oxidation of ethanol to acetaldehyde are alcohol dehydrogenase (ADH), catalase, and the microsomal ethanol-oxidizing system. ADH is the principal enzyme responsible for this process in humans and other mammals (8, 55, 56). Aldehyde dehydrogenase (ALDH) catalyzes the next step of converting of acetaldehyde to acetic acid, which is then activated to acetyl CoA. Acetaldehyde is a chemically reactive metabolite and has been thought to be involved in ethanol intoxication, alcohol sensitivity and alcoholism (31, 57, 70, 74). Interestingly, human ADH and ALDH exhibit highly complex molecular forms with widely different kinetic properties, tissue specificity and racial distributions (2, 8, 56, 65). This paper summarizes some of the recent advances about these two enzymes. Ethanol metabolism and acetaldehyde toxicity in various tissues and organs of individuals with genetically different forms of ADH and ALDH isoenzymes also will be examined." @default.
- W48347913 created "2016-06-24" @default.
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- W48347913 date "1989-01-01" @default.
- W48347913 modified "2023-10-16" @default.
- W48347913 title "Genetic Polymorphism and Properties of Human Alcohol and Aldehyde Dehydrogenases: Implications for Ethanol Metabolism and Toxicity" @default.
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- W48347913 doi "https://doi.org/10.1007/978-1-4612-4514-8_17" @default.
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