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- W48447101 abstract "AIM: To determine whether Saiko-keishioto (TJ-10), a Japanese herbal medicine, could protect liver injury induced by gut ischemia/reperfusion (I/R), and to investigate the role of NO.METHODS: Male Wistar rats were exposed to 30-min gut ischemia followed by 60 min of reperfusion. Intravital microscopywas used to monitor leukocyte recruitment. Plasma tumor necrosis factor (TNF) levels and alanine aminotransferase (ALT) activities were measured. T]-10 1 gl(kg.d) was intragastrically administered to rats for 7 d. A NO synthase inhibitor was administered.RESULTS: In control rats, gut I/R elicited increases in the number of stationary leukocytes, and plasma TNF levels and ALT activities were mitigated by pretreatment withT]-10. Pretreatment with the NO synthase inhibitor diminished the protective effects of TJ-10 on leukostasis in the liver, and the increase of plasma TNF levels and ALT activities. Pretreatment with TL-10 increased plasma nitrite/nitrate levels.CONCLUSION: TJ-10 attenuates the gut I/R-induced hepalJc microvascular dysfunction and sequential hepatocellular injury via enhancement of NO production." @default.
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- W48447101 date "2004-01-01" @default.
- W48447101 modified "2023-09-26" @default.
- W48447101 title "Japanese herbal medicine, Saiko-keishi-to, prevents gutischemia／reperfusion-induced liver injurv in rats via nitric oxide" @default.
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