Matches in SemOpenAlex for { <https://semopenalex.org/work/W48473742> ?p ?o ?g. }
Showing items 1 to 78 of
78
with 100 items per page.
- W48473742 endingPage "835" @default.
- W48473742 startingPage "831" @default.
- W48473742 abstract "Caveolae are vesicular invaginations of the plasma membrane. Caveolin-1 is the structural protein component of caveolae. Caveolin-1 participates in signal transduction processes by acting as a scaffolding protein that concentrates, organizes and functional regulates signaling molecules within caveolar membranes. Cigarette smoke, a source of oxidants, is an environmental hazard that causes pulmonary emphysema. Recently, we reported that the development of cigarette smoking-induced pulmonary emphysema was inhibited in caveolin-1 null mice, which do not express caveolin-1. We demonstrated that lack of caveolin-1 expression in lung fibroblasts dramatically inhibited premature senescence induced by oxidants contained in cigarette smoke. Mechanistically, we uncovered that premature senescence of lung fibroblasts induced by oxidative stress occurred through activation of an ataxia telangiectasia-mutated (ATM)/p53-depedent pathway following sequestration of the catalytic subunit of protein phosphatase 2A (PP2A-C), an inhibitor of ATM, by caveolin-1 into caveolar membranes. We propose caveolin-1 as a key player of a novel signaling pathway that links cigarette smoke to premature senescence of lung fibroblasts and development of pulmonary emphysema." @default.
- W48473742 created "2016-06-24" @default.
- W48473742 creator A5050392667 @default.
- W48473742 creator A5059287929 @default.
- W48473742 date "2009-08-10" @default.
- W48473742 modified "2023-10-17" @default.
- W48473742 title "Caveolin-1, cellular senescence and pulmonary emphysema" @default.
- W48473742 cites W1761524483 @default.
- W48473742 cites W1775613062 @default.
- W48473742 cites W1968572771 @default.
- W48473742 cites W1971592740 @default.
- W48473742 cites W1987631879 @default.
- W48473742 cites W2023179617 @default.
- W48473742 cites W2024209230 @default.
- W48473742 cites W2123070281 @default.
- W48473742 cites W2158169335 @default.
- W48473742 cites W2315512556 @default.
- W48473742 doi "https://doi.org/10.18632/aging.100079" @default.
- W48473742 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/2815740" @default.
- W48473742 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/20157570" @default.
- W48473742 hasPublicationYear "2009" @default.
- W48473742 type Work @default.
- W48473742 sameAs 48473742 @default.
- W48473742 citedByCount "33" @default.
- W48473742 countsByYear W484737422012 @default.
- W48473742 countsByYear W484737422013 @default.
- W48473742 countsByYear W484737422014 @default.
- W48473742 countsByYear W484737422015 @default.
- W48473742 countsByYear W484737422016 @default.
- W48473742 countsByYear W484737422017 @default.
- W48473742 countsByYear W484737422019 @default.
- W48473742 countsByYear W484737422020 @default.
- W48473742 countsByYear W484737422022 @default.
- W48473742 countsByYear W484737422023 @default.
- W48473742 crossrefType "journal-article" @default.
- W48473742 hasAuthorship W48473742A5050392667 @default.
- W48473742 hasAuthorship W48473742A5059287929 @default.
- W48473742 hasBestOaLocation W484737421 @default.
- W48473742 hasConcept C185592680 @default.
- W48473742 hasConcept C2779403975 @default.
- W48473742 hasConcept C2780870201 @default.
- W48473742 hasConcept C49866891 @default.
- W48473742 hasConcept C522857546 @default.
- W48473742 hasConcept C62478195 @default.
- W48473742 hasConcept C86803240 @default.
- W48473742 hasConcept C95444343 @default.
- W48473742 hasConceptScore W48473742C185592680 @default.
- W48473742 hasConceptScore W48473742C2779403975 @default.
- W48473742 hasConceptScore W48473742C2780870201 @default.
- W48473742 hasConceptScore W48473742C49866891 @default.
- W48473742 hasConceptScore W48473742C522857546 @default.
- W48473742 hasConceptScore W48473742C62478195 @default.
- W48473742 hasConceptScore W48473742C86803240 @default.
- W48473742 hasConceptScore W48473742C95444343 @default.
- W48473742 hasIssue "9" @default.
- W48473742 hasLocation W484737421 @default.
- W48473742 hasLocation W484737422 @default.
- W48473742 hasLocation W484737423 @default.
- W48473742 hasLocation W484737424 @default.
- W48473742 hasOpenAccess W48473742 @default.
- W48473742 hasPrimaryLocation W484737421 @default.
- W48473742 hasRelatedWork W1539163551 @default.
- W48473742 hasRelatedWork W1596371849 @default.
- W48473742 hasRelatedWork W2044537148 @default.
- W48473742 hasRelatedWork W2074278428 @default.
- W48473742 hasRelatedWork W2076606695 @default.
- W48473742 hasRelatedWork W2151324251 @default.
- W48473742 hasRelatedWork W2369569451 @default.
- W48473742 hasRelatedWork W2383379241 @default.
- W48473742 hasRelatedWork W3030950172 @default.
- W48473742 hasRelatedWork W4231730192 @default.
- W48473742 hasVolume "1" @default.
- W48473742 isParatext "false" @default.
- W48473742 isRetracted "false" @default.
- W48473742 magId "48473742" @default.
- W48473742 workType "article" @default.