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• W48485870 abstract "Insulin-like peptide 3 (INSL3) belongs to the insulin/relaxin family of structurally related peptides, and mediates its effects via the G protein-coupled receptor, RXFP2 (relaxin family peptide receptor 2). Extensive mutagenesis studies have revealed the molecular determinants of INSL3/RXFP2 binding, and developed several INSL3-based antagonists. The major physiological effects of INSL3 are observed within the reproductive system, where the peptide/receptor pair is essential for testes descent during development. Additional endocrine roles for INSL3 are emerging in bone metabolism and cancer metastasis." @default.
• W48485870 created "2016-06-24" @default.
• W48485870 creator A5024721527 @default.
• W48485870 date "2009-01-01" @default.
• W48485870 modified "2023-09-27" @default.
• W48485870 title "Insulin-Like Peptide 3 (INSL3)" @default.
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• W48485870 doi "https://doi.org/10.1016/b978-008055232-3.64020-6" @default.
• W48485870 hasPublicationYear "2009" @default.
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