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- W48650643 abstract "Event Abstract Back to Event Turning excitation into inhibition: Glu-GABA exchange as an endogenous defensive mechanism in epilepsy Laszlo Heja1*, Gabriella Nyitrai1, Peter Barabas1, Balint Lasztoczi1, Miklos Palkovits2 and Julianna Kardos1 1 Department of Neurochemistry,Hungarian Academy of Sciences, Hungary 2 Semmelweis University and Hungarian Academy of Sciences, Hungary The balance between excitation and inhibition is of crucial importance for the proper functioning of the nervous system. Many neurological disorders, like epilepsy or ischemia are characterized by a disruption of this balance, usually by the abnormal intensification of excitatory signals. Here we demonstrate that the intense excitation leads to the emergence of a previously unrecognized endogenous defense mechanism by which the extracellular excitatory glutamate (Glu) is exchanged for the inhibitory γ-amino-butyric acid (GABA). This process is maintained by the concerted action of the glial Glu and GABA transporters, using the glial Glu/Na+ uptake as the driving force for the release of GABA. Taking advantage of the exclusive appearance of the Glu-GABA exchange mechanism during and following intense excitation periods, it may serve as an ideal target for the development of new pathomechanism-specific therapeutics. Conference: 12th Meeting of the Hungarian Neuroscience Society, Budapest, Hungary, 22 Jan - 24 Jan, 2009. Presentation Type: Poster Presentation Topic: Pathophysiology and neurology - degenerative disorders Citation: Heja L, Nyitrai G, Barabas P, Lasztoczi B, Palkovits M and Kardos J (2009). Turning excitation into inhibition: Glu-GABA exchange as an endogenous defensive mechanism in epilepsy. Front. Syst. Neurosci. Conference Abstract: 12th Meeting of the Hungarian Neuroscience Society. doi: 10.3389/conf.neuro.01.2009.04.152 Copyright: The abstracts in this collection have not been subject to any Frontiers peer review or checks, and are not endorsed by Frontiers. They are made available through the Frontiers publishing platform as a service to conference organizers and presenters. The copyright in the individual abstracts is owned by the author of each abstract or his/her employer unless otherwise stated. Each abstract, as well as the collection of abstracts, are published under a Creative Commons CC-BY 4.0 (attribution) licence (https://creativecommons.org/licenses/by/4.0/) and may thus be reproduced, translated, adapted and be the subject of derivative works provided the authors and Frontiers are attributed. For Frontiers’ terms and conditions please see https://www.frontiersin.org/legal/terms-and-conditions. Received: 05 Mar 2009; Published Online: 05 Mar 2009. * Correspondence: Laszlo Heja, Department of Neurochemistry,Hungarian Academy of Sciences, Budapest, Hungary, heja.laszlo@ttk.mta.hu Login Required This action requires you to be registered with Frontiers and logged in. To register or login click here. Abstract Info Abstract The Authors in Frontiers Laszlo Heja Gabriella Nyitrai Peter Barabas Balint Lasztoczi Miklos Palkovits Julianna Kardos Google Laszlo Heja Gabriella Nyitrai Peter Barabas Balint Lasztoczi Miklos Palkovits Julianna Kardos Google Scholar Laszlo Heja Gabriella Nyitrai Peter Barabas Balint Lasztoczi Miklos Palkovits Julianna Kardos PubMed Laszlo Heja Gabriella Nyitrai Peter Barabas Balint Lasztoczi Miklos Palkovits Julianna Kardos Related Article in Frontiers Google Scholar PubMed Abstract Close Back to top Javascript is disabled. Please enable Javascript in your browser settings in order to see all the content on this page." @default.
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- W48650643 date "2009-01-01" @default.
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- W48650643 title "Turning excitation into inhibition: Glu-GABA exchange as an endogenous defensive mechanism in epilepsy" @default.
- W48650643 doi "https://doi.org/10.3389/conf.neuro.01.2009.04.152" @default.
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