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- W4865771 abstract "Key Points Plasma homocysteine concentrations are increased in postmenopausal women in comparison with premenopausal women. High homocysteine levels, low folate and vitamin B12 status have been associated with osteoporotic fractures in some, but not all, studies. Whether high levels of homocysteine have a direct effect on bone or whether the effect is mediated through folate and/or vitamin B12 deficiencies is uncertain. Supplementation with folate and vitamin B12 may also reduce the risk of fractures. Whether the risk reduction is due to the lowering of serum homocysteine or an increase in B12/folate is not known. Although the evidence is limited, supplemental folic acid or vitamin B12 for the treatment of osteoporosis or primary prevention of fracture is not recommended." @default.
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- W4865771 date "2013-01-01" @default.
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- W4865771 title "Postmenopausal Homocysteine, Vitamin B12, Folate Levels and Bone Metabolism: A Focus on Fractures" @default.
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- W4865771 doi "https://doi.org/10.1007/978-1-62703-373-2_7" @default.
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