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- W48697445 abstract "Non-Hodgkin’s lymphoma (NHL) is the fifth most common cancer among men and women in the United States [1]. High-dose chemotherapy with autoHCT offers curative potential to some patients who are not cured with frontline combination chemotherapy and/or radiotherapy. However, autoHCT is not the optimal therapy for patients with marrow involvement or for some patients with indolent disease. Conventional myeloablative allogeneic hematopoietic cell transplantation (HCT) has unequivocally demonstrated a reduction in relapse/progression compared with autoHCT in both indolent and aggressive NHL but is also associated with significant treatment-related mortality (TRM) [2, 3]. Over the last decade, the use of nonmyeloablative or reduced intensity conditioning (RIT) regimens has increased with an associated reduction in upfront toxicity in most published studies. RIT regimens broaden patient eligibility since older patients, patients with comorbid conditions, and heavily pretreated patients, including those who have failed a prior autoHCT can better tolerate such regimens. This approach incorporates immunosuppressive doses of chemotherapy and/or radiotherapy to achieve a mixed donor-host hematopoietic chimeric state, thus facilitating development of a donor immune-mediated graft-versus-lymphoma (GVL) effect." @default.
- W48697445 created "2016-06-24" @default.
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- W48697445 date "2009-11-27" @default.
- W48697445 modified "2023-09-27" @default.
- W48697445 title "Non-Hodgkin’s Lymphoma: Allogeneic Reduced Intensity Conditioning" @default.
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- W48697445 doi "https://doi.org/10.1007/978-1-59745-478-0_8" @default.
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