Matches in SemOpenAlex for { <https://semopenalex.org/work/W48761731> ?p ?o ?g. }
- W48761731 endingPage "274" @default.
- W48761731 startingPage "237" @default.
- W48761731 abstract "The cloning of the Ca2+ 0-sensing receptor (CaR), which is a G protein-coupled receptor (GPCR) that responds to changes in the extracellular calcium concentration (Ca2+ 0), has enabled identification of several inherited disorders of Ca2+ 0 homeostasis that result from either activating or inactivating mutations of this recently recognized receptor. Inactivating mutations produce hypercalcemic syndromes, while activating mutations produce a form of hypocalcemia resembling hypoparathyroidism. In addition to elucidating the molecular pathogenesis of these disorders exhibiting “resistance” or “oversensitivity” to actions of Ca2+ 0 that are mediated by the CaR, the identification of inherited diseases of this receptor has afforded “experiments-in-nature” that have clarified substantially the CaR’ s normal physiological roles in parathyroid and kidney. This chapter will briefly describe the discovery of the CaR and its roles in normal physiology, delineate in more detail the principal clinical and biochemical features of these inherited diseases of the receptor and illustrate how these disorders have clarified further the CaR’ s physiological roles. More detailed descriptions of the molecular biology, regulation and other properties of this novel receptor and its role in regulating diverse tissues, both those involved and those uninvolved in systemic mineral ion homeostasis, may be found in recent reviews (1,2)." @default.
- W48761731 created "2016-06-24" @default.
- W48761731 creator A5038281830 @default.
- W48761731 date "2000-01-01" @default.
- W48761731 modified "2023-09-25" @default.
- W48761731 title "Disorders Resulting from Inactivating or Activating Mutations in the Ca2+ 0-Sensing Receptor" @default.
- W48761731 cites W1578432561 @default.
- W48761731 cites W1853215604 @default.
- W48761731 cites W1965630351 @default.
- W48761731 cites W1966419963 @default.
- W48761731 cites W1967740404 @default.
- W48761731 cites W1967777479 @default.
- W48761731 cites W1968434592 @default.
- W48761731 cites W1969540263 @default.
- W48761731 cites W1969619665 @default.
- W48761731 cites W1971284998 @default.
- W48761731 cites W1972476373 @default.
- W48761731 cites W1973798197 @default.
- W48761731 cites W1975297178 @default.
- W48761731 cites W1975367389 @default.
- W48761731 cites W1975608515 @default.
- W48761731 cites W1977019491 @default.
- W48761731 cites W1980535565 @default.
- W48761731 cites W1984252569 @default.
- W48761731 cites W1985882769 @default.
- W48761731 cites W1986261291 @default.
- W48761731 cites W1986975365 @default.
- W48761731 cites W1994723791 @default.
- W48761731 cites W1998616639 @default.
- W48761731 cites W1999458397 @default.
- W48761731 cites W2005637545 @default.
- W48761731 cites W2005913521 @default.
- W48761731 cites W2009441758 @default.
- W48761731 cites W2009683617 @default.
- W48761731 cites W2010599278 @default.
- W48761731 cites W2011539758 @default.
- W48761731 cites W2016094313 @default.
- W48761731 cites W2016818162 @default.
- W48761731 cites W2021485426 @default.
- W48761731 cites W2022460283 @default.
- W48761731 cites W2023770323 @default.
- W48761731 cites W2024322966 @default.
- W48761731 cites W2024616274 @default.
- W48761731 cites W2027466826 @default.
- W48761731 cites W2034085896 @default.
- W48761731 cites W2034819530 @default.
- W48761731 cites W2038415768 @default.
- W48761731 cites W2040320063 @default.
- W48761731 cites W2042484533 @default.
- W48761731 cites W2042661577 @default.
- W48761731 cites W2044373921 @default.
- W48761731 cites W2047030131 @default.
- W48761731 cites W2047907147 @default.
- W48761731 cites W2050419480 @default.
- W48761731 cites W2056497873 @default.
- W48761731 cites W2059313753 @default.
- W48761731 cites W2060757756 @default.
- W48761731 cites W2065390805 @default.
- W48761731 cites W2066958101 @default.
- W48761731 cites W2069454620 @default.
- W48761731 cites W2071587854 @default.
- W48761731 cites W2071855678 @default.
- W48761731 cites W2072893670 @default.
- W48761731 cites W2074098367 @default.
- W48761731 cites W2074993713 @default.
- W48761731 cites W2075307506 @default.
- W48761731 cites W2076095627 @default.
- W48761731 cites W2076606204 @default.
- W48761731 cites W2077973233 @default.
- W48761731 cites W2079475485 @default.
- W48761731 cites W2079732641 @default.
- W48761731 cites W2080440162 @default.
- W48761731 cites W2081227689 @default.
- W48761731 cites W2086486301 @default.
- W48761731 cites W2087865703 @default.
- W48761731 cites W2091303924 @default.
- W48761731 cites W2092946338 @default.
- W48761731 cites W2106218459 @default.
- W48761731 cites W2109206081 @default.
- W48761731 cites W2109484905 @default.
- W48761731 cites W2111072371 @default.
- W48761731 cites W2113376778 @default.
- W48761731 cites W2113902080 @default.
- W48761731 cites W2127202100 @default.
- W48761731 cites W2145930493 @default.
- W48761731 cites W2153170303 @default.
- W48761731 cites W2160214772 @default.
- W48761731 cites W2163868721 @default.
- W48761731 cites W2167767264 @default.
- W48761731 cites W2170949021 @default.
- W48761731 cites W2326971455 @default.
- W48761731 cites W2335952874 @default.
- W48761731 cites W2337614773 @default.
- W48761731 cites W2344483515 @default.
- W48761731 cites W3148204587 @default.
- W48761731 cites W4229920882 @default.
- W48761731 cites W4234276148 @default.
- W48761731 cites W4238891881 @default.