Matches in SemOpenAlex for { <https://semopenalex.org/work/W48809503> ?p ?o ?g. }
- W48809503 endingPage "603" @default.
- W48809503 startingPage "593" @default.
- W48809503 abstract "We studied the subcellular mechanisms of the negative force-frequency relationship in rat myocardium by measuring 1) intracellular Ca2+ transients by indo-1 fluorometry and 2) intracellular pH (pHi) and phosphate compounds with 31P-nuclear magnetic resonance (NMR). The data were compared with those from guinea pig hearts, which show a positive force-frequency relationship. By increasing the pacing rate from 3 Hz to 5 Hz, the peak positive first derivative of left ventricular pressure (LVdP/dt) in rat heart decreased by 10 +/- 1% (n = 6). In contrast to this negative inotropic response, simultaneously measured peak Ca2+ transients increased by 6 +/- 1%. Guinea pig heart (n = 6) showed an increase in peak positive LVdP/dt (33 +/- 1%) which was associated with an increase in peak Ca2+ transients (8 +/- 1%). Under equivalent experimental conditions in an NMR spectrometer, this increase in the pacing rate did not affect intracellular levels of phosphate compounds in either rat (n = 6) or guinea pig heart (n = 6). In contrast, pHi showed a decrease of 0.031 +/- 0.006 pH units in rat heart, while no changes were observed in guinea pig heart. These results suggest that in physiological rat myocardium, pHi is susceptible to changes in the stimulus frequency and may affect the Ca(2+)-responsiveness of contractile proteins, which results in the negative force-frequency relationship." @default.
- W48809503 created "2016-06-24" @default.
- W48809503 creator A5006485588 @default.
- W48809503 creator A5055719084 @default.
- W48809503 creator A5056725944 @default.
- W48809503 creator A5079219122 @default.
- W48809503 creator A5083646143 @default.
- W48809503 date "1996-01-01" @default.
- W48809503 modified "2023-09-23" @default.
- W48809503 title "Mechanism of the Negative Force-Frequency Relationship in Physiologically Intact Rat Ventricular Myocardium" @default.
- W48809503 cites W1486158936 @default.
- W48809503 cites W1544106935 @default.
- W48809503 cites W1980859633 @default.
- W48809503 cites W1996140321 @default.
- W48809503 cites W2006059631 @default.
- W48809503 cites W2017470658 @default.
- W48809503 cites W2018379942 @default.
- W48809503 cites W2020914291 @default.
- W48809503 cites W2025975686 @default.
- W48809503 cites W2036717675 @default.
- W48809503 cites W2042681520 @default.
- W48809503 cites W2049400347 @default.
- W48809503 cites W2050551491 @default.
- W48809503 cites W2059747067 @default.
- W48809503 cites W2075021708 @default.
- W48809503 cites W2076437210 @default.
- W48809503 cites W2088762770 @default.
- W48809503 cites W2090135050 @default.
- W48809503 cites W2091119680 @default.
- W48809503 cites W2094276784 @default.
- W48809503 cites W2110608925 @default.
- W48809503 cites W2111163569 @default.
- W48809503 cites W2115471525 @default.
- W48809503 cites W2119318441 @default.
- W48809503 cites W2126478397 @default.
- W48809503 cites W2130909570 @default.
- W48809503 cites W2131159446 @default.
- W48809503 cites W2150341329 @default.
- W48809503 cites W2150582811 @default.
- W48809503 cites W2164170735 @default.
- W48809503 cites W2173622786 @default.
- W48809503 cites W2231651666 @default.
- W48809503 cites W2415208667 @default.
- W48809503 cites W2418782425 @default.
- W48809503 cites W2418817212 @default.
- W48809503 doi "https://doi.org/10.1253/jcj.60.593" @default.
- W48809503 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/8889662" @default.
- W48809503 hasPublicationYear "1996" @default.
- W48809503 type Work @default.
- W48809503 sameAs 48809503 @default.
- W48809503 citedByCount "17" @default.
- W48809503 countsByYear W488095032012 @default.
- W48809503 countsByYear W488095032013 @default.
- W48809503 countsByYear W488095032015 @default.
- W48809503 countsByYear W488095032016 @default.
- W48809503 countsByYear W488095032017 @default.
- W48809503 countsByYear W488095032022 @default.
- W48809503 crossrefType "journal-article" @default.
- W48809503 hasAuthorship W48809503A5006485588 @default.
- W48809503 hasAuthorship W48809503A5055719084 @default.
- W48809503 hasAuthorship W48809503A5056725944 @default.
- W48809503 hasAuthorship W48809503A5079219122 @default.
- W48809503 hasAuthorship W48809503A5083646143 @default.
- W48809503 hasBestOaLocation W488095031 @default.
- W48809503 hasConcept C121332964 @default.
- W48809503 hasConcept C12554922 @default.
- W48809503 hasConcept C126322002 @default.
- W48809503 hasConcept C134018914 @default.
- W48809503 hasConcept C134897140 @default.
- W48809503 hasConcept C155710745 @default.
- W48809503 hasConcept C185592680 @default.
- W48809503 hasConcept C2777953023 @default.
- W48809503 hasConcept C2778815084 @default.
- W48809503 hasConcept C39133596 @default.
- W48809503 hasConcept C46141821 @default.
- W48809503 hasConcept C55493867 @default.
- W48809503 hasConcept C71924100 @default.
- W48809503 hasConcept C79879829 @default.
- W48809503 hasConcept C84393581 @default.
- W48809503 hasConcept C86803240 @default.
- W48809503 hasConceptScore W48809503C121332964 @default.
- W48809503 hasConceptScore W48809503C12554922 @default.
- W48809503 hasConceptScore W48809503C126322002 @default.
- W48809503 hasConceptScore W48809503C134018914 @default.
- W48809503 hasConceptScore W48809503C134897140 @default.
- W48809503 hasConceptScore W48809503C155710745 @default.
- W48809503 hasConceptScore W48809503C185592680 @default.
- W48809503 hasConceptScore W48809503C2777953023 @default.
- W48809503 hasConceptScore W48809503C2778815084 @default.
- W48809503 hasConceptScore W48809503C39133596 @default.
- W48809503 hasConceptScore W48809503C46141821 @default.
- W48809503 hasConceptScore W48809503C55493867 @default.
- W48809503 hasConceptScore W48809503C71924100 @default.
- W48809503 hasConceptScore W48809503C79879829 @default.
- W48809503 hasConceptScore W48809503C84393581 @default.
- W48809503 hasConceptScore W48809503C86803240 @default.
- W48809503 hasIssue "8" @default.
- W48809503 hasLocation W488095031 @default.