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- W48882267 abstract "The use of high dose of methotrexate (HDM), has been suggested as a mean of obtaining potentially cytotoxic cerebrospinal fluid (CSF) drug levels. The present study describes the pharmacokinetics in plasma and CSF for at least 65 hours after administratrion of HDM, and allows the simultaneous interpretation of the CSF and plasma available data. Methotrexate (MTX) concentrations in plasma and CSF were monitored and analyzed in a child suffering from a protuberancial primitive neuroectodermal tumor (PNET) wearing an external ventricular derivation of CSF. The pharmacokinetic parameters obtained allow us to predict CSF MTX concentrations from a more accessible fluid (plasma). Moreover, this study would allow to theoretically calculate different dose regimens in order to reach specific CSF concentrations." @default.
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- W48882267 date "2001-01-01" @default.
- W48882267 modified "2023-09-27" @default.
- W48882267 title "Plasma and cerebrospinal fluid pharmacokinetic of methotrexate in a child suffering from a PNET" @default.
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- W48882267 doi "https://doi.org/10.1007/bf02711770" @default.
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