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- W48931039 endingPage "167" @default.
- W48931039 startingPage "153" @default.
- W48931039 abstract "The evolution of mammalian brains has involved a spectacular amount of parcellation and diversification. Each brain region receives its own characteristic set of inputs and contains its own characteristic circuits, which together define its functional role in producing behavior. Yet we understand little about what guides particular sets of afferents to project to a given brain region, or about how presumptive brain regions are directed to form particular circuits, either in a developmental or an evolutionary sense. By using developmental manipulations that mimic potential evolutionary changes, such as changes in the number or type of sensory afferents, we have been able to gain insight into how evolution may have co-opted mechanisms underlying developmental plasticity in the brain. We have used two different experimental manipulations, retinotopic map compression and cross-modal plasticity, that lead to compensatory innervation and result in recovery of function in central sensory circuits during development. By understanding how the brain compensates for developmental alterations in input, it is possible to gain insight into how developmental programs may have been used or modified over evolutionary time to produce specialized, adaptive circuitry in more derived species." @default.
- W48931039 created "2016-06-24" @default.
- W48931039 creator A5026360822 @default.
- W48931039 date "2007-01-01" @default.
- W48931039 modified "2023-09-26" @default.
- W48931039 title "Compensatory Innervation in Development and Evolution" @default.
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