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- W48941805 abstract "In medicine today, much effort is being made to develop new protease inhibitors for use as anticoagulants in multiple disease states. Deep venous thrombosis and pulmonary embolism, in particular, are major medical problems in the developed world. Similarly, myocardial infarction, stroke, and peripheral vascular disease are arterial thromboses for which the addition of anticoagulant/antiplatelet agents have resulted in reduction of adverse events upon presentation and improved treatment outcomes. Therapies for both venous and arterial thrombosis represent major growth areas in the pharmaceutical industry. The basis for many of these anticoagulant agents has arisen from naturally occurring protease inhibitors in man and in other creatures. This interest arises from a need in clinical medicine to improve anticoagulant therapeutics for both naturally occurring disease processes and new medical therapeutic interventions. Characterization of nature’s inhibitors can provide for the development of important therapeutics. Development of novel anticoagulants needs to consider the major clot-forming enzymes in the hemostatic system, thrombin and factor Xa. Thus, protease inhibitors to these two enzymes have the potential to serve as anticoagulants, i.e., to inhibit hemostatic clot formation. In this manuscript, the term “anticoagulants” will be used to describe agents that interfere with proteins that participate in the plasma coagulation system which has been traditionally termed the coagulation cascade. The term “antiplatelet agents” will be used to describe entities that specifically interfere with platelet activation only. Both anticoagulants and antiplatelet agents prevent thrombosis in blood vessels. The term “antithrombotics” will be used in this manuscript to indicate combined anticoagulant and antiplatelet activity of agents." @default.
- W48941805 created "2016-06-24" @default.
- W48941805 creator A5066630966 @default.
- W48941805 date "2000-01-01" @default.
- W48941805 modified "2023-10-05" @default.
- W48941805 title "Inhibitors of Thrombin and Factor Xa" @default.
- W48941805 cites W1043612374 @default.
- W48941805 cites W1174423596 @default.
- W48941805 cites W130392956 @default.
- W48941805 cites W1484846535 @default.
- W48941805 cites W1486977846 @default.
- W48941805 cites W1493019391 @default.
- W48941805 cites W1497473690 @default.
- W48941805 cites W1499963171 @default.
- W48941805 cites W1504930481 @default.
- W48941805 cites W1517896461 @default.
- W48941805 cites W1518197977 @default.
- W48941805 cites W1523525659 @default.
- W48941805 cites W1524888592 @default.
- W48941805 cites W1525152388 @default.
- W48941805 cites W1526369051 @default.
- W48941805 cites W1533112727 @default.
- W48941805 cites W1536230526 @default.
- W48941805 cites W1538605908 @default.
- W48941805 cites W1545585691 @default.
- W48941805 cites W1549602366 @default.
- W48941805 cites W1552156688 @default.
- W48941805 cites W1552647544 @default.
- W48941805 cites W1553470727 @default.
- W48941805 cites W1560970554 @default.
- W48941805 cites W1563465184 @default.
- W48941805 cites W156998644 @default.
- W48941805 cites W1584647394 @default.
- W48941805 cites W1585928558 @default.
- W48941805 cites W1593430977 @default.
- W48941805 cites W1594492118 @default.
- W48941805 cites W1595140077 @default.
- W48941805 cites W1601949152 @default.
- W48941805 cites W1607595973 @default.
- W48941805 cites W1618720360 @default.
- W48941805 cites W1664950994 @default.
- W48941805 cites W1891400877 @default.
- W48941805 cites W1964499190 @default.
- W48941805 cites W1964858690 @default.
- W48941805 cites W1968617774 @default.
- W48941805 cites W1972999624 @default.
- W48941805 cites W197552768 @default.
- W48941805 cites W1977452105 @default.
- W48941805 cites W1977497608 @default.
- W48941805 cites W1987360507 @default.
- W48941805 cites W1996305694 @default.
- W48941805 cites W1996729024 @default.
- W48941805 cites W1999859798 @default.
- W48941805 cites W2000606571 @default.
- W48941805 cites W2002261292 @default.
- W48941805 cites W200349053 @default.
- W48941805 cites W2007781471 @default.
- W48941805 cites W2021933008 @default.
- W48941805 cites W2023186463 @default.
- W48941805 cites W2024913717 @default.
- W48941805 cites W2025326836 @default.
- W48941805 cites W2026740600 @default.
- W48941805 cites W2027876001 @default.
- W48941805 cites W2032444176 @default.
- W48941805 cites W2035307463 @default.
- W48941805 cites W2036702421 @default.
- W48941805 cites W2038841215 @default.
- W48941805 cites W2039976180 @default.
- W48941805 cites W2049354886 @default.
- W48941805 cites W2055604490 @default.
- W48941805 cites W2060297306 @default.
- W48941805 cites W2061627303 @default.
- W48941805 cites W2064129448 @default.
- W48941805 cites W2064160073 @default.
- W48941805 cites W2066822578 @default.
- W48941805 cites W2067327367 @default.
- W48941805 cites W2068475410 @default.
- W48941805 cites W2071817594 @default.
- W48941805 cites W2073566194 @default.
- W48941805 cites W2073950118 @default.
- W48941805 cites W2075196907 @default.
- W48941805 cites W2079487514 @default.
- W48941805 cites W2081753893 @default.
- W48941805 cites W2097908856 @default.
- W48941805 cites W2099363777 @default.
- W48941805 cites W2109137392 @default.
- W48941805 cites W2117984921 @default.
- W48941805 cites W2121897924 @default.
- W48941805 cites W2129420509 @default.
- W48941805 cites W2132412188 @default.
- W48941805 cites W2138849164 @default.
- W48941805 cites W2139151815 @default.
- W48941805 cites W2141373630 @default.
- W48941805 cites W2156192484 @default.
- W48941805 cites W2160439330 @default.
- W48941805 cites W2162084919 @default.
- W48941805 cites W2221015914 @default.
- W48941805 cites W2273423172 @default.