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- W49071118 endingPage "88" @default.
- W49071118 startingPage "63" @default.
- W49071118 abstract "Chronic wounds are characterized by a failure to re-epithelialize and by defective production as well as remodeling of extracellular matrix (ECM). Acute incisional and excisional skin wounds account for over 4.5 million medical procedures per year in the US. Therapies that accelerate normal skin repair and production of stronger scar tissue are desirable, because they lead to quicker recovery from burns and surgical operations, particularly in older individuals. Therapies that heal chronic wounds save tissue that might otherwise be lost to necrosis and infection as well as save the life of the patient in some cases. Deep incisions are repaired by stitching the wound edges together, resulting in a thin line of scar tissue on the surface of the skin. To increase the area that can be covered by a skin autograft, surgeons use meshed split-thickness skin grafts (MSTSGs). A wide variety of topical agents have been employed to accelerate the normal repair process and produce stronger scar tissue in acute wounds of normal skin. Application of healing accelerants as early as possible after wounding is desirable, because of the cascade affects that carry through to later stages of healing. No dental restorative materials have the same physical and chemical characteristics of natural tooth tissues. The current technique to restore periodontal tissue is guided by tissue regeneration, which does not produce predictably good outcomes. Cornea is unable to regenerate if limbal tissue that provides the stem cells for regeneration is compromised. If a part of the limbus in either eye remains undamaged, pieces of this tissue can be removed and cultured on human amniotic membrane to form a larger sheet. Pieces of this epithelial sheet can then be transplanted as an autogeneic sectorial or a ring graft to regenerate and maintain the damaged cornea." @default.
- W49071118 created "2016-06-24" @default.
- W49071118 creator A5082538161 @default.
- W49071118 date "2006-01-01" @default.
- W49071118 modified "2023-09-25" @default.
- W49071118 title "Regenerative Medicine of Skin, Hair, Dental Tissues, and Cornea" @default.
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