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- W49094511 abstract "Amac: Uyku apnesinde inflamatuar surec, endotelial fonksiyon bozuklugu ve oksidatif stresin iliskisinin incelenmesi. Yontem: Ucuncu basamak bir referans hastanesinde planlanan calismaya 63 yeni tani almis uyku apnesi hastasi ve 9 basit horlama hastasi dahil edildi. Hastalar ek sistemik hastaliklar ve laboratuvar testleri acisindan degerlendirildi, fizik muayeneleri yapildi. Rutin laboratuvar testlerine ek olarak oksidatif stres belirtecleri (leptin, RBP), endothelial fonksiyon bozuklugu belirtecleri (ICAM-I, VCAM-I) ve inflamatuar surec belirtecleri (CRP, IL-6, TNF-alfa, izoprostan) acisindan analiz edildi. Hastalar apne hipopne indekslerine gore 4 alt gruba ayrildi. Gruplar arasinda capraz analizler yapilarak gruplar arasindaki farkliliklar test edildi. Bulgular: Izoprostan seviyesi ile ortalama apne suresi arasinda hafif, maksimum apne suresi arasinda orta seviyede korrelasyon gozlendi. Hastalarin yas ortalamasi ile leptin ve VCAM-I arasinda zayif pozitif korrelasyon gozlenirken, CRP seviyesi ile ortalama yas arasinda zayif negatif korelasyon izlendi. Leptin seviyesi ile vucut kitle indeksi ve abdominal cevre arasinda orta seviyeli korelasyon izlendi. ICAM-I seviyesi ile vucut kitle endeksi ve karin cevresi arasinda zayif korelasyon mevcuttu. Sonuc: Calismamiz sonucunda oksidatif stress ile uyku apnesi arasinda iliski oldugunu tespit ettik. Bu iliski uyku apnesine eslik eden komorbid hastaliklarin aciklanmasinda onemli bir basamak olabilir. Bu konuda yapilacak olan yeni calismalarda bu inflamatuar surecin basamaklari ve klinik yansimalari aciklanmaya calisilmalidir." @default.
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- W49094511 date "2014-08-01" @default.
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- W49094511 title "The evaluation of inflammatory process, endothelial dysfunction and oxidative stress in sleep apnea" @default.
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- W49094511 doi "https://doi.org/10.2399/jmu.2014002007" @default.
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