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- W4911492 abstract "Objectives To identify potential biomarkers for early preeclampsia (PE) with placental lesions consistent with maternal vascular underperfusion (MVU) using a novel proteomic approach. Methods A longitudinal study included uncomplicated singleton pregnant women whose samples were collected between 24 and 42 weeks (controls: n = 50, total samples = 199). Cases were women with early PE (delivered n = 44) and the samples were collected at the time of diagnosis. Proteomic profiles were analyzed using aptamer-based multiplexed proteomic technology which measured 1129 proteins. Log transformed and normalized protein concentrations in uncomplicated pregnancies were modeled using locally weighted linear quantile regression to establish the 10th and 90th percentiles of their distribution as a function of gestational age. Sensitivity for each protein in the identification of early PE with MVU at fixed 90% specificity was computed. Confidence intervals (CI) for sensitivity estimates were obtained by using a bootstrap procedure. Results (1) Twenty-five proteins had a sensitivity of at least 80% (at 90% specificity) for the identification of early PE with MVU; (2) four proteins (soluble tyrosine-protein kinase receptor-1, PlGF, and two newly-identified biomarkers had more than 90% sensitivity to identify such disorder; (3) each of these 4 proteins had at least 91% with 95% CI between 73% and 100% when confirmed by bootstrap; and (4) the median coefficient of variation (CV) for 1129 proteins was 6.07% (IQR = 4.4–8.5%). Conclusions Four proteins each had at least 90% sensitivity and specificity in the identification of patients with PE. The panel included two novel markers. Protein expression profiles in maternal plasma in normal pregnancy and early PE with MVU (red dots). (For interpretation of the references to color in this figure legend, the reader is referred to the web version of this article.) Disclosures P. Chaemsaithong: None. R. Romero: None. A.L. Tarca: None. Z. Xu: None. A.I. Ahmed: None. S.S. Hassan: None. L. Yeo: None. T. Chaiworapongsa: None." @default.
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- W4911492 date "2015-01-01" @default.
- W4911492 modified "2023-09-27" @default.
- W4911492 title "[90-OR]" @default.
- W4911492 doi "https://doi.org/10.1016/j.preghy.2014.10.094" @default.
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