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- W49159448 abstract "The immune system accomplishes the specific recognition of foreign antigens, in the absence of reactivity to self antigens, by: (a) creating an enormous repertoire of cells each expressing an unique variable (V) region (clonotype); (b) purging the repertoire of cells whose V regions recognize self-antigenic determinants, and (c) enabling each immunogen to selectively stimulate only those cells whose V regions are high affinity for determinants of that immunogen. While this overall strategy is pervasive among both the B and T cell systems of immunocompetent animals, there is enormous variation in the extent of repertoire diversity and the means by which repertoire diversity is achieved, even among the B cell subsets of an individual. Thus, prior to any overt antigenic stimulation, the murine B cell system consists of at least four distinct B cell subsets differing in repertoire diversity and responsiveness to antigenic stimulation. After immunization, the repertoire is supplemented by the generation of memory B cells, which in some, but not all cases, enables the refinement of that portion of the repertoire that initially recognized the immunogen. The existence of a mechanism that improves the pre-existing repertoire suggests that the initial repertoire may have been functionally deficient in the spectrum of V regions capable of high affinity recognition of certain antigens. In this sense the generation of memory B cells can fill these gaps, the strategy for V region diversification used to generate and propagate memory B cells would appear to be both unique and extremely powerful." @default.
- W49159448 created "2016-06-24" @default.
- W49159448 creator A5041603977 @default.
- W49159448 date "1998-01-01" @default.
- W49159448 modified "2023-10-13" @default.
- W49159448 title "Repertoire Diversification of Primary vs Memory B Cell Subsets" @default.
- W49159448 cites W103281325 @default.
- W49159448 cites W1189774283 @default.
- W49159448 cites W1482979607 @default.
- W49159448 cites W1488045575 @default.
- W49159448 cites W1493244741 @default.
- W49159448 cites W1528534342 @default.
- W49159448 cites W1558347537 @default.
- W49159448 cites W1575406202 @default.
- W49159448 cites W1576195593 @default.
- W49159448 cites W1592366453 @default.
- W49159448 cites W1598444116 @default.
- W49159448 cites W1604654907 @default.
- W49159448 cites W1610962799 @default.
- W49159448 cites W1747312855 @default.
- W49159448 cites W1900925913 @default.
- W49159448 cites W1962967194 @default.
- W49159448 cites W1963528685 @default.
- W49159448 cites W1963562796 @default.
- W49159448 cites W1964895771 @default.
- W49159448 cites W1968819337 @default.
- W49159448 cites W1972529116 @default.
- W49159448 cites W1973295889 @default.
- W49159448 cites W1978408586 @default.
- W49159448 cites W1981197474 @default.
- W49159448 cites W1981267088 @default.
- W49159448 cites W1982289564 @default.
- W49159448 cites W1983122167 @default.
- W49159448 cites W1983763219 @default.
- W49159448 cites W1984387553 @default.
- W49159448 cites W1984982539 @default.
- W49159448 cites W1987949096 @default.
- W49159448 cites W1988335634 @default.
- W49159448 cites W1988903541 @default.
- W49159448 cites W1989560823 @default.
- W49159448 cites W1991545892 @default.
- W49159448 cites W2000107365 @default.
- W49159448 cites W2000566565 @default.
- W49159448 cites W2002376591 @default.
- W49159448 cites W2007138237 @default.
- W49159448 cites W2010130789 @default.
- W49159448 cites W2012428299 @default.
- W49159448 cites W2016208323 @default.
- W49159448 cites W2016822118 @default.
- W49159448 cites W2018306897 @default.
- W49159448 cites W2020264015 @default.
- W49159448 cites W2020902883 @default.
- W49159448 cites W2026622170 @default.
- W49159448 cites W2039715322 @default.
- W49159448 cites W2042487497 @default.
- W49159448 cites W2045025888 @default.
- W49159448 cites W2045417932 @default.
- W49159448 cites W2052438035 @default.
- W49159448 cites W2052733766 @default.
- W49159448 cites W2052820133 @default.
- W49159448 cites W2054488343 @default.
- W49159448 cites W2054798265 @default.
- W49159448 cites W2057141478 @default.
- W49159448 cites W2062128699 @default.
- W49159448 cites W2062166667 @default.
- W49159448 cites W2065118688 @default.
- W49159448 cites W2069501059 @default.
- W49159448 cites W2069679620 @default.
- W49159448 cites W2073838442 @default.
- W49159448 cites W2074268860 @default.
- W49159448 cites W2076747220 @default.
- W49159448 cites W2081719515 @default.
- W49159448 cites W2084492613 @default.
- W49159448 cites W2091988724 @default.
- W49159448 cites W2097004161 @default.
- W49159448 cites W2098471323 @default.
- W49159448 cites W2102098396 @default.
- W49159448 cites W2106903691 @default.
- W49159448 cites W2112970530 @default.
- W49159448 cites W2116370657 @default.
- W49159448 cites W2120130414 @default.
- W49159448 cites W2122016469 @default.
- W49159448 cites W2130871951 @default.
- W49159448 cites W2131839976 @default.
- W49159448 cites W2132080325 @default.
- W49159448 cites W2134544592 @default.
- W49159448 cites W2142132827 @default.
- W49159448 cites W2143352720 @default.
- W49159448 cites W2145378376 @default.
- W49159448 cites W2145524613 @default.
- W49159448 cites W2146089552 @default.
- W49159448 cites W2148570305 @default.
- W49159448 cites W2148855679 @default.
- W49159448 cites W2151651734 @default.
- W49159448 cites W2155047219 @default.
- W49159448 cites W2155702835 @default.
- W49159448 cites W2159149406 @default.
- W49159448 cites W2166317148 @default.