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• W49185927 endingPage "458" @default.
• W49185927 startingPage "458" @default.
• W49185927 abstract "The interleukin-1 receptor type I (IL-1RtI) plays an important role in the biological effects of IL-1, but regulation of its surface and gene expression remains unknown. We found that occupancy of 2-15% of the IL-1 surface receptor results in dramatic down-regulation of IL-1RtI both at the mRNA and cell surface level in murine D10S cells, a subline of T-helper type 2 cells. At these low occupancy levels (3 x 10(-12) to 3 x 10(-13) M), the reduction in IL-1RtI surface expression appears at 24 hr and continues to 48 and 72 hr. At the mRNA level, low occupancy of the IL-1R results in decreased IL-1RtI mRNA stability; steady state half-life of the IL-1RtI mRNA is reduced from 6 to 1 hr after exposure to 3 x 10(-12) M IL-1. This down-regulation of IL-1RtI by IL-1 is blocked by cycloheximide, suggesting de novo protein synthesis is necessary for decreased RNA stability. Low concentrations of human IL-1 beta, murine and rabbit IL-1 alpha or beta similarly down-regulated IL-1RtI, whereas low concentrations of human IL-1 alpha failed to reduce the receptor surface expression, despite inducing a full proliferative response. We also observed that the effect of IL-1 on this down-regulation was not through protein kinase C (PKC), since PMA rapidly increased IL-1RtI mRNA levels within 30 min and persisted for 24 hr. IL-2 up-regulated IL-1RtI in D10S cells at both mRNA and protein levels. These results demonstrate that low occupancy of IL-1 receptors induces down-regulation of IL-1RtI surface as well as mRNA expression. The regulation of IL-1RtI gene expression may be one of the mechanisms by which IL-1-mediated events are controlled." @default.
• W49185927 created "2016-06-24" @default.
• W49185927 creator A5027297476 @default.
• W49185927 creator A5028234430 @default.
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• W49185927 date "1991-09-01" @default.
• W49185927 modified "2023-09-30" @default.
• W49185927 title "Interleukin-1 downregulates gene and surface expression of interleukin-1 receptor type I by destabilizing its mRNA whereas interleukin-2 increases its expression" @default.
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• W49185927 doi "https://doi.org/10.1016/1043-4666(91)90099-y" @default.
• W49185927 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/1384735" @default.
• W49185927 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/1533388" @default.
• W49185927 hasPublicationYear "1991" @default.
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